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Title: Behavioral profiles in frontal lobe epilepsy: Autobiographic memory versus mood impairment.
Austin Authors: Rayner, Genevieve ;Jackson, Graeme D ;Wilson, Sarah J
Affiliation: Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Victoria, Australia
The Florey Institute of Neuroscience and Mental Health, Brain Research Institute, The University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: 13-Jan-2015
Publication information: Epilepsia 2015; 56(2): 225-33
Abstract: Autobiographic memory encompasses the encoding and retrieval of episodes, people, and places encountered in everyday life. It can be impaired in both epilepsy and frontal lobe damage. Here, we performed an initial investigation of how autobiographic memory is impacted by chronic frontal lobe epilepsy (FLE) together with its underlying pathology.We prospectively studied a series of nine consecutive patients with medically refractory FLE, relative to 24 matched healthy controls. Seven of the nine patients had frontal lobe structural abnormalities. Episodic and semantic autobiographic memory functioning was profiled, and factors associated with impaired autobiographic memory were identified among epileptologic, neuroimaging, neuropsychiatric, and cognitive variables including auditory-verbal and visual memory, and the executive function of cognitive control.Results showed that the FLE group experienced significantly higher rates of autobiographic memory and mood disturbance (p < 0.001), with detailed assessment of individual patients revealing two profiles of impairment, primarily characterized by cognitive or mood disturbance. Five of the patients (56%) exhibited significant episodic autobiographic memory deficits, whereas in three of these, knowledge of semantic autobiographic facts was preserved. Four of them also had reduced cognitive control. Mood disorder was largely unrelated to poor autobiographic memory. In contrast, the four cases with preserved autobiographic memory were notable for their past or current depressive symptoms.These findings provide preliminary data that frontal lobe seizure activity with its underlying pathology may selectively disrupt large-scale cognitive or affective networks, giving rise to different neurobehavioral profiles that may be used to inform clinical management.
Gov't Doc #: 25582326
DOI: 10.1111/epi.12902
Type: Journal Article
Subjects: Autobiographical memory
Frontal lobe
Epilepsy, Frontal Lobe.diagnosis.physiopathology
Executive Function.physiology
Memory Disorders.diagnosis.physiopathology
Memory, Episodic
Middle Aged
Mood Disorders.physiopathology
Neuropsychological Tests
Young Adult
Appears in Collections:Journal articles

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