Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12560
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dc.contributor.authorAlmatroodi, Saleh Aen
dc.contributor.authorMcDonald, Christine Fen
dc.contributor.authorCollins, Allison Len
dc.contributor.authorDarby, Ian Aen
dc.contributor.authorPouniotis, Dodie Sen
dc.date.accessioned2015-05-16T02:16:26Z
dc.date.available2015-05-16T02:16:26Z
dc.date.issued2015-01-02en
dc.identifier.citationCancer Genomics & Proteomics; 12(1): 39-48en
dc.identifier.govdoc25560643en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/12560en
dc.description.abstractThe most commonly reported primary lung cancer subtype is adenocarcinoma, which is associated with a poor prognosis and short survival. Proteomic studies on human body fluids such as bronchoalveolar lavage fluid (BALF) have become essential methods for biomarker discovery, examination of tumor pathways and investigation of potential treatments.This study used quantitative proteomics to investigate the up-regulation of novel proteins in BALF from patients with primary lung adenocarcinoma in order to identify potential biomarkers.BALF samples from individuals with and without primary lung adenocarcinoma were analyzed using liquid chromatography-mass spectrometry.One thousand and one hundred proteins were identified, 33 of which were found to be consistently overexpressed in all lung adenocarcinoma samples compared to non-cancer controls. A number of overexpressed proteins have been previously shown to be related to lung cancer progression including S100-A8, annexin A1, annexin A2, thymidine phosphorylase and transglutaminase 2.The overexpression of a number of specific proteins in BALF from patients with primary lung adenocarcinoma may be used as a potential biomarker for lung adenocarcinoma.en
dc.language.isoenen
dc.subject.otherBALFen
dc.subject.otherLung adenocarcinomaen
dc.subject.otherbiomarkeren
dc.subject.othermass spectrophotometryen
dc.subject.otherproteinen
dc.subject.otherquantitative proteomicsen
dc.titleQuantitative proteomics of bronchoalveolar lavage fluid in lung adenocarcinoma.en
dc.typeJournal Articleen
dc.identifier.journaltitleCancer genomics & proteomicsen
dc.identifier.affiliationCancer and Tissue Repair Laboratory, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australiaen
dc.identifier.affiliationInstitute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationCancer and Tissue Repair Laboratory, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia Applied Medical Sciences College, Qassim University, Buraidah, Saudi Arabia.en
dc.description.pages39-48en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/25560643en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
crisitem.author.deptInstitute for Breathing and Sleep-
crisitem.author.deptRespiratory and Sleep Medicine-
crisitem.author.deptInstitute for Breathing and Sleep-
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