Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12519
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dc.contributor.authorTailby, Chrisen
dc.contributor.authorMasterton, Richard A Jen
dc.contributor.authorHuang, Jenny Yen
dc.contributor.authorJackson, Graeme Den
dc.contributor.authorAbbott, David Fen
dc.date.accessioned2015-05-16T02:13:38Z-
dc.date.available2015-05-16T02:13:38Z-
dc.date.issued2014-11-24en
dc.identifier.citationNeuroimage 2014; 106(): 428-40en
dc.identifier.govdoc25463462en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/12519en
dc.description.abstractResting state functional connectivity (rFC) is used to identify functionally related brain areas without requiring subjects to perform specific tasks. Previous work suggests that prior brain state, as determined by the activity engaged in immediately prior to collection of resting state data, can influence the networks recovered by rFC analyses. We determined the prevalence and network specificity of rFC changes induced by manipulations of prior state (including an unstructured (unconstrained) state, and language and motor tasks). Three blocks of rest data (one after each of the specified prior states) were acquired on each of 25 subjects. We hypothesised that prior state induced changes in rFC would be greatest within the networks most actively recruited by that prior state. Changes in rFC were greatest following the motor task and, contrary to our hypothesis, were not network specific. This was demonstrated by comparing (1) the timecourses within a set of ROIs selected on the basis of task-related de/activation, and (2) seed-based whole brain voxel-wise connectivity maps, seeded from local maxima in the task-related de/activation maps. Changes in connectivity strength tended to manifest as increases in rFC relative to that in the unstructured rest state, with change maps resembling partially complete maps of the primary sensory cortices and the cognitive control network. The majority of rFC changes occurred in areas moderately (but not weakly) connected to the seeds. Constrained prior states were associated with lower across-participant variance in rFC. This systematic investigation of the effect of prior brain state on rFC indicates that the rFC changes induced by prior brain state occur both in brain networks related to that brain activity and in networks nominally unrelated to that brain activity.en
dc.language.isoenen
dc.subject.otherBOLDen
dc.subject.otherBrain networksen
dc.subject.otherFunctional MRIen
dc.subject.otherFunctional connectivityen
dc.subject.otherResting stateen
dc.titleResting state functional connectivity changes induced by prior brain state are not network specific.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeuroImageen
dc.identifier.affiliationDepartment of Psychology, The University of Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Medicine, The University of Melbourne, Victoria, Australiaen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Austin Hospital, Victoria, Australiaen
dc.identifier.doi10.1016/j.neuroimage.2014.11.037en
dc.description.pages428-40en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/25463462en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.fulltextNo Fulltext-
crisitem.author.deptClinical Neuropsychology-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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