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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12465
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dc.contributor.authorGu, X Hen
dc.contributor.authorLiu, J Jen
dc.contributor.authorDillon, J Sen
dc.contributor.authorNayler, W Gen
dc.date.accessioned2015-05-16T02:10:00Z
dc.date.available2015-05-16T02:10:00Z
dc.date.issued1989-02-01en
dc.identifier.citationBritish Journal of Pharmacology; 96(2): 262-4en
dc.identifier.govdoc2538185en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12465en
dc.description.abstractThe effect of endothelin, a potent vasoconstrictor polypeptide, on three types of calcium antagonist binding sites was examined, in rat cardiac membrane fragments. Endothelin 10 nM affected neither the affinity nor density of dihydropyridine binding sites. At concentrations of 10(-12)-10(-7) M, endothelin failed to displace bound (+)-[3H]-PN 200/110, (-)-[3H]-D888 and (+)-cis-[3H]-diltiazem. These results suggest that the calcium antagonist binding sites associated with L-type calcium channels are not the primary site of action of endothelin.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherBinding, Competitiveen
dc.subject.otherCalcium Channel Blockers.metabolismen
dc.subject.otherCalcium Channelsen
dc.subject.otherDiltiazem.metabolismen
dc.subject.otherEndothelinsen
dc.subject.otherFemaleen
dc.subject.otherIn Vitro Techniquesen
dc.subject.otherIsradipineen
dc.subject.otherOxadiazoles.metabolismen
dc.subject.otherPeptides.metabolism.pharmacologyen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred Strainsen
dc.subject.otherReceptors, Nicotinic.drug effectsen
dc.subject.otherVerapamil.analogs & derivatives.metabolismen
dc.titleThe failure of endothelin to displace bound, radioactively-labelled, calcium antagonists (PN 200/110, D888 and diltiazem).en
dc.typeJournal Articleen
dc.identifier.journaltitleBritish journal of pharmacologyen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria.en
dc.description.pages262-4en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2538185en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
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