Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12422
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBlair, Amy Ren
dc.contributor.authorStrube, M Len
dc.contributor.authorProietto, Josephen
dc.contributor.authorAndrikopoulos, Sofianosen
dc.date.accessioned2015-05-16T02:07:10Z
dc.date.available2015-05-16T02:07:10Z
dc.date.issued2014-10-08en
dc.identifier.citationHormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Me´tabolisme 2014; 47(3): 184-93en
dc.identifier.govdoc25295419en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12422en
dc.description.abstractDiets to decrease body weight have limited success in achieving and importantly maintaining this weight loss long-term. It has recently been suggested that energy intake can be regulated by the amount of protein ingested, termed the protein leverage hypothesis. In this study, we determined whether a high protein diet would be effective in achieving and maintaining weight loss in a genetically obese model, the New Zealand Obese (NZO) mouse. NZO and C57BL/6J (C57) control mice were fed a high protein or chow diet for 5 weeks from weaning (3 weeks of age). Body weight and food intake were determined. Mice on the same diet were bred to produce offspring that were fed either a chow or high protein diet. Body weight, food intake, and glucose tolerance were determined. Feeding NZO and C57 mice a high protein diet for 5 weeks resulted in reduced food intake and consequently energy intake and body weight gain compared with mice on a chow diet. NZO mice fed a high protein diet showed a significant improvement in glucose tolerance compared with their chow-fed counterparts, while no difference was seen in C57 mice fed chow or protein diet. The offspring of NZO mice that were fed a high protein diet during gestation and weaning were also lighter and displayed improved glucose tolerance compared with chow fed animals. We conclude that a high protein diet is a reasonable strategy to reduce body weight gain and improve glucose tolerance in the NZO mouse, a polygenic model of obesity.en
dc.language.isoenen
dc.titleImproving glucose tolerance by reducing weight gain in a polygenic obese mouse model: use of a high protein diet.en
dc.typeJournal Articleen
dc.identifier.journaltitleHormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolismeen
dc.identifier.affiliationThe University of Melbourne, Department of Medicine (Austin Health), Austin Hospital, Melbourne, Victoria, Australiaen
dc.identifier.doi10.1055/s-0034-1389991en
dc.description.pages184-93en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/25295419en
dc.type.austinJournal Articleen
local.name.researcherProietto, Joseph
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptMedicine (University of Melbourne)-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

12
checked on Mar 28, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.