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https://ahro.austin.org.au/austinjspui/handle/1/12363
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Langan, Katherine M | - |
dc.contributor.author | Jacob, Jovan | - |
dc.contributor.author | Li, Jian | - |
dc.contributor.author | Nation, Roger L | - |
dc.contributor.author | Bellomo, Rinaldo | - |
dc.contributor.author | Howden, Benjamin P | - |
dc.contributor.author | Johnson, Paul D R | - |
dc.date.accessioned | 2015-05-16T02:03:15Z | - |
dc.date.available | 2015-05-16T02:03:15Z | - |
dc.date.issued | 2014-09-01 | - |
dc.identifier.citation | Critical Care and Resuscitation; 16(3): 190-6 | en_US |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/12363 | en |
dc.description.abstract | To test whether a prolonged 3-hour infusion of meropenem 500mg achieves an equivalent proportion of time above the minimal inhibitory concentration (MIC) (%TMIC) to that of meropenem 1000mg given over 30 minutes.A randomised crossover study in 10 critically ill patients.We administered meropenem as a 1000mg, 30-minute infusion or as a 500mg, 3-hour infusion. We determined serial plasma concentrations for each dosing episode and performed comparisons of %TMIC at different MICs.The percentage of time that meropenem was above its MIC.For low MICs (≤2 mg/L), both regimens attained a %TMIC >40% in all patients. For an MIC of 4mg/L, this target was attained in all but one patient, but with an MIC of 8mg/L, three patients in each group had a %TMIC <40%. There was no difference in target attainment between the two regimens for MICs up to 8mg/L. There was marked variability in the pharmacokinetic and hence the pharmacokinetic-pharmacodynamic parameters between individuals. Several patients had elevated creatinine clearances and, with both regimens, their target attainment was poor.Meropenem at 1000mg over 30 minutes achieved a similar %TMIC to meropenem at 500mg given over 3 hours. Meropenem pharmacokinetics were highly variable from individual to individual. | en_US |
dc.language.iso | en | en |
dc.subject.other | Adult | en |
dc.subject.other | Aged | en |
dc.subject.other | Anti-Bacterial Agents.administration & dosage.blood.pharmacokinetics | en |
dc.subject.other | Critical Illness | en |
dc.subject.other | Cross-Over Studies | en |
dc.subject.other | Female | en |
dc.subject.other | Humans | en |
dc.subject.other | Infusions, Intravenous.methods | en |
dc.subject.other | Male | en |
dc.subject.other | Microbial Sensitivity Tests | en |
dc.subject.other | Middle Aged | en |
dc.subject.other | Pilot Projects | en |
dc.subject.other | Prospective Studies | en |
dc.subject.other | Thienamycins.administration & dosage.blood.pharmacokinetics | en |
dc.title | Pharmacokinetics of short versus extended infusion meropenem dosing in critically ill patients: a pilot study. | en_US |
dc.type | Journal Article | en_US |
dc.identifier.journaltitle | Critical Care and Resuscitation | en_US |
dc.identifier.affiliation | Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia | en_US |
dc.identifier.affiliation | Infectious Diseases | en_US |
dc.identifier.affiliation | Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia | en_US |
dc.description.pages | 190-6 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/25161021 | en |
dc.type.content | Text | en_US |
dc.type.austin | Journal Article | en |
local.name.researcher | Bellomo, Rinaldo | |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | Journal Article | - |
crisitem.author.dept | Intensive Care | - |
crisitem.author.dept | Data Analytics Research and Evaluation (DARE) Centre | - |
crisitem.author.dept | Infectious Diseases | - |
crisitem.author.dept | Microbiology | - |
crisitem.author.dept | Infectious Diseases | - |
Appears in Collections: | Journal articles |
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