Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12340
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dc.contributor.authorHollands, Simone-
dc.contributor.authorLim, Yen Ying-
dc.contributor.authorBuckley, Rachel F-
dc.contributor.authorPietrzak, Robert H-
dc.contributor.authorSnyder, Peter J-
dc.contributor.authorAmes, David-
dc.contributor.authorEllis, Kathryn A-
dc.contributor.authorHarrington, Karra-
dc.contributor.authorLautenschlager, Nicola T-
dc.contributor.authorMartins, Ralph N-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorRowe, Christopher C-
dc.contributor.authorMaruff, Paul-
dc.date.accessioned2015-05-16T02:01:32Z
dc.date.available2015-05-16T02:01:32Z
dc.date.issued2015-
dc.identifier.citationJournal of Alzheimer's Disease : Jad; 43(2): 677-86en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12340en
dc.description.abstractThe detection of early Alzheimer's disease (AD) can rely on subjective and informant reports of cognitive impairment. However, relationships between subjective cognitive impairment, objectively measured cognitive function, and amyloid-β (Aβ) biomarkers remain unclear.To determine the extent to which impairment or decline in subjective and informant rated cognitive impairment was associated with memory in healthy older adults with high Aβ.Healthy older adults (n = 289) enrolled in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study were studied at baseline. Pittsburgh Compound B was used to determine Aβ status at baseline. At baseline and 18 months assessments, subjective memory impairment was assessed using the Memory Complaint Questionnaire and the Short Form of the Informant Questionnaire on Cognitive Decline in the Elderly. Cognition was measured using the Cogstate Brief Battery.At baseline, there were no differences between low and high Aβ groups in subjective or informant-rated cognitive impairment, depressive and anxiety symptoms, or cognitive function. Longitudinal analyses showed moderate decline in learning and working memory over the 18 months in the high Aβ group. However there was no change over time in subjective or informant-rated cognitive impairment, depressive and anxiety symptoms, or cognition in either Aβ group.Although healthy older adults with high Aβ levels show decline in learning and working memory over 18 months, subjective or informant ratings of cognitive impairment do not change over the same period suggesting subjective cognitive impairment may have limited utility for the very early identification of AD.en
dc.language.isoenen
dc.subject.otherAmyloiden
dc.subject.othercognitiveen
dc.subject.otherdepressionen
dc.subject.othersubjective memory impairmenten
dc.titleAmyloid-β related memory decline is not associated with subjective or informant rated cognitive impairment in healthy adults.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Alzheimer's disease : JADen
dc.identifier.affiliationDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USAen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia Cogstate Ltd., Melbourne, Victoria, Australiaen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia Department of Neurology, Warren Alpert School of Medicine of Brown University & Lifespan Hospital System, Providence, RI, USAen
dc.identifier.affiliationDepartment of Neurology, Warren Alpert School of Medicine of Brown University & Lifespan Hospital System, Providence, RI, USAen
dc.identifier.affiliationAcademic Unit for Psychiatry of Old Age, St. Vincent's Health, The University of Melbourne, Kew, Victoria, Australia National Ageing Research Institute, Parkville, Victoria, Australiaen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia School of Psychology, University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationDepartment of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationAcademic Unit for Psychiatry of Old Age, St. Vincent's Health, The University of Melbourne, Kew, Victoria, Australia School of Psychiatry and Clinical Neurosciences and Western Australian Centre for Health and Aging, University of Western Australia, Perth, Australiaen
dc.identifier.affiliationSchool of Psychology, Royal Melbourne Institute of Technology, Bundoora, Victoria, Australiaen
dc.identifier.affiliationCentre of Excellence for Alzheimer's Disease Research and Care, Edith Cowan University, Joondalup, Western Australia, Australiaen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.3233/JAD-140678en
dc.description.pages677-86en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/25114076en
dc.type.contentTexten
dc.type.austinJournal Articleen
local.name.researcherMasters, Colin L
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMolecular Imaging and Therapy-
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