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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12339
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dc.contributor.authorAckermann, Uween
dc.contributor.authorPlougastel, Lucieen
dc.contributor.authorGoh, Yit Wooien
dc.contributor.authorYeoh, Shinn Deeen
dc.contributor.authorScott, Andrew Men
dc.date.accessioned2015-05-16T02:01:27Z
dc.date.available2015-05-16T02:01:27Z
dc.date.issued2014-07-24en
dc.identifier.citationApplied Radiation and Isotopes : Including Data, Instrumentation and Methods For Use in Agriculture, Industry and Medicine 2014; 94(): 72-6en
dc.identifier.govdoc25113535en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12339en
dc.description.abstractThe synthesis of [(18)F]2-fluoroethyl azide and its subsequent click reaction with 5-ethynyl-2'-deoxyuridine (EDU) to form [(18)F]FLETT was performed using an iPhase FlexLab module. The implementation of a vacuum distillation method afforded [(18)F]2-fluoroethyl azide in 87±5.3% radiochemical yield. The use of Cu(CH3CN)4PF6 and TBTA as catalyst enabled us to fully automate the [(18)F]FLETT synthesis without the need for the operator to enter the radiation field. [(18)F]FLETT was produced in higher overall yield (41.3±6.5%) and shorter synthesis time (67min) than with our previously reported manual method (32.5±2.5% in 130min).en
dc.language.isoenen
dc.subject.otherAutomationen
dc.subject.otherClick chemistryen
dc.subject.otherFluorine-18en
dc.subject.otherVacuum distillationen
dc.titleImproved synthesis of [(18)F]FLETT via a fully automated vacuum distillation method for [(18)F]2-fluoroethyl azide purification.en
dc.typeJournal Articleen
dc.identifier.journaltitleApplied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicineen
dc.identifier.affiliationThe University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationLudwig Institute for Cancer Research, Melbourne Branch, Victoria, Australiaen
dc.identifier.affiliationDepartment of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationEcole National Supérior de Chimie de Rennes, Rennes, France.en
dc.identifier.doi10.1016/j.apradiso.2014.07.009en
dc.description.pages72-6en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/25113535en
dc.type.austinJournal Articleen
local.name.researcherAckermann, Uwe
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
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