Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12304
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dc.contributor.authorHolmes, Natasha E-
dc.contributor.authorTurnidge, John D-
dc.contributor.authorMunckhof, Wendy J-
dc.contributor.authorRobinson, J Owen-
dc.contributor.authorKorman, Tony M-
dc.contributor.authorO'Sullivan, Matthew V N-
dc.contributor.authorAnderson, Tara L-
dc.contributor.authorRoberts, Sally A-
dc.contributor.authorWarren, Sanchia J C-
dc.contributor.authorCoombs, Geoffrey W-
dc.contributor.authorTan, Hui-Leen-
dc.contributor.authorGao, Wei-
dc.contributor.authorJohnson, Paul D R-
dc.contributor.authorHowden, Benjamin P-
dc.date.accessioned2015-05-16T01:58:04Z
dc.date.available2015-05-16T01:58:04Z
dc.date.issued2014-07-16-
dc.identifier.citationJournal of Clinical Microbiology 2014; 52(9): 3384-93en_US
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12304en
dc.description.abstractAn elevated vancomycin MIC is associated with poor outcomes in Staphylococcus aureus bacteremia (SAB) and is reported in patients with methicillin-susceptible S. aureus (MSSA) bacteremia in the absence of vancomycin treatment. Here, using DNA microarray and phenotype analysis, we investigated the genetic predictors and accessory gene regulator (agr) function and their relationship with elevated vancomycin MIC using blood culture isolates from a multicenter binational cohort of patients with SAB. Specific clonal complexes were associated with elevated (clonal complex 8 [CC8] [P < 0.001]) or low (CC22 [P < 0.001], CC88 [P < 0.001], and CC188 [P = 0.002]) vancomycin MIC. agr dysfunction (P = 0.014) or agr genotype II (P = 0.043) were also associated with an elevated vancomycin MIC. Specific resistance and virulence genes were also linked to an elevated vancomycin MIC, including blaZ (P = 0.002), sea (P < 0.001), clfA (P < 0.001), splA (P = 0.001), and the arginine catabolic mobile element (ACME) locus (P = 0.02). These data suggest that inherent organism characteristics may explain the link between elevated vancomycin MICs and poor outcomes in patients with SAB, regardless of the antibiotic treatment received. A consideration of clonal specificity should be included in future research when attempting to ascertain treatment effects or clinical outcomes.en_US
dc.language.isoenen
dc.subject.otherAdolescenten
dc.subject.otherAdulten
dc.subject.otherAgeden
dc.subject.otherAnti-Bacterial Agents.pharmacologyen
dc.subject.otherBacteremia.microbiologyen
dc.subject.otherBacterial Proteins.geneticsen
dc.subject.otherChilden
dc.subject.otherChild, Preschoolen
dc.subject.otherCohort Studiesen
dc.subject.otherDrug Toleranceen
dc.subject.otherFemaleen
dc.subject.otherGenotypeen
dc.subject.otherHumansen
dc.subject.otherInfanten
dc.subject.otherInfant, Newbornen
dc.subject.otherMaleen
dc.subject.otherMicroarray Analysisen
dc.subject.otherMicrobial Sensitivity Testsen
dc.subject.otherMiddle Ageden
dc.subject.otherProspective Studiesen
dc.subject.otherStaphylococcal Infections.microbiologyen
dc.subject.otherStaphylococcus aureus.drug effects.genetics.isolation & purificationen
dc.subject.otherTrans-Activators.geneticsen
dc.subject.otherVancomycin.pharmacologyen
dc.subject.otherVirulence Factors.geneticsen
dc.subject.otherYoung Adulten
dc.titleGenetic and molecular predictors of high vancomycin MIC in Staphylococcus aureus bacteremia isolates.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of Clinical Microbiologyen_US
dc.identifier.affiliationDepartment of Infectious Diseases, Monash Health, Clayton, Victoria, Australia Department of Medicine, Monash University, Clayton, Victoria, Australiaen_US
dc.identifier.affiliationSA Pathology, Women's and Children's Hospital, North Adelaide, South Australia, Australia Department of Paediatrics, Pathology and Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia, Australiaen_US
dc.identifier.affiliationDepartment of Microbiology, Monash University, Clayton, Victoria, Australia Microbiological Diagnostic Unit, Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Microbiology and Infectious Diseases, PathWest Laboratory Medicine-WA, Royal Perth Hospital, Perth, Western Australia, Australia Australian Collaborating Centre for Enterococcus and Staphylococcus Species (ACCESS) Typing and Research, School of Biomedical Sciences, Curtin University, Perth, Western Australia, Australiaen_US
dc.identifier.affiliationDepartment of Infectious Diseases, Royal Hobart Hospital, Hobart, Tasmania, Australia Department of Medicine, University of Tasmania, Hobart, Tasmania, Australiaen_US
dc.identifier.affiliationCentre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, New South Wales, Australia Department of Medicine, University of Sydney, Sydney, New South Wales, Australiaen_US
dc.identifier.affiliationInfection Management Services, Princess Alexandra Hospital, Wolloongabba, Queensland, Australia Department of Medicine, University of Queensland, St Lucia, Queensland, Australiaen_US
dc.identifier.affiliationInfectious Diseasesen_US
dc.identifier.affiliationMicrobiologyen_US
dc.identifier.affiliationAuckland District Health Board, Auckland, New Zealand.en_US
dc.identifier.doi10.1128/JCM.01320-14en_US
dc.description.pages3384-93en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/25031442en
dc.type.contentTexten_US
dc.type.austinJournal Articleen
local.name.researcherHolmes, Natasha E
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptInfectious Diseases-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
crisitem.author.deptInfectious Diseases-
crisitem.author.deptInfectious Diseases-
crisitem.author.deptMicrobiology-
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