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https://ahro.austin.org.au/austinjspui/handle/1/12276| Title: | Autobiographical narratives relate to Alzheimer's disease biomarkers in older adults. | Austin Authors: | Buckley, Rachel F;Saling, Michael M ;Irish, Muireann;Ames, David;Rowe, Christopher C ;Villemagne, Victor L ;Lautenschlager, Nicola T;Maruff, Paul;Macaulay, S Lance;Martins, Ralph N;Szoeke, Cassandra;Masters, Colin L ;Rainey-Smith, Stephanie R;Rembach, Alan;Savage, Greg;Ellis, Kathryn A | Institutional Author: | Australian Imaging Biomarkers and Lifestyle Study of Ageing (AIBL) Research Group | Affiliation: | Centre of Excellence for Alzheimer's Disease Research and Care,School of Medical Sciences,Edith Cowan University,Perth,Western Australia,Australia Melbourne School of Psychological Sciences,University of Melbourne,Melbourne,Victoria,Australia The Florey Institute of Neuroscience and Mental Health,University of Melbourne,Melbourne,Victoria,Australia ARC Centre of Excellence in Cognition and its Disorders,Macquarie University,Sydney,New South Wales,Australia Commonwealth Scientific Industrial Research Organization,Melbourne,Victoria,Australia The Academic Unit for Psychiatry of Old Age,St. Vincent's Hospital,Department of Psychiatry,University of Melbourne,Melbourne,Victoria,Australia Department of Nuclear Medicine and Centre for PET,Austin Health,Heidelberg,Australia National Aging Research Institute,Melbourne,Victoria,Australia Neuroscience Research Australia,Sydney,New South Wales,Australia |
Issue Date: | 27-Jun-2014 | Publication information: | International Psychogeriatrics / Ipa 2014; 26(10): 1737-46 | Abstract: | Autobiographical memory (ABM), personal semantic memory (PSM), and autonoetic consciousness are affected in individuals with mild cognitive impairment (MCI) but their relationship with Alzheimer's disease (AD) biomarkers are unclear.Forty-five participants (healthy controls (HC) = 31, MCI = 14) completed the Episodic ABM Interview and a battery of memory tests. Thirty-one (HC = 22, MCI = 9) underwent β-amyloid positron emission tomography (PET) and magnetic resonance (MR) imaging. Fourteen participants (HC = 9, MCI = 5) underwent one imaging modality.Unlike PSM, ABM differentiated between diagnostic categories but did not relate to AD biomarkers. Personal semantic memory was related to neocortical β-amyloid burden after adjusting for age and apolipoprotein E (APOE) ɛ4. Autonoetic consciousness was not associated with AD biomarkers, and was not impaired in MCI.Autobiographical memory was impaired in MCI participants but was not related to neocortical amyloid burden, suggesting that personal memory systems are impacted by differing disease mechanisms, rather than being uniformly underpinned by β-amyloid. Episodic and semantic ABM impairment represent an important AD prodrome. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/12276 | DOI: | 10.1017/S1041610214001136 | Journal: | International psychogeriatrics / IPA | URL: | https://pubmed.ncbi.nlm.nih.gov/24969443 | Type: | Journal Article |
| Appears in Collections: | Journal articles |
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