Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12244
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dc.contributor.authorIschia, Joseph Jen
dc.contributor.authorPatel, Oneelen
dc.contributor.authorBolton, Damien Men
dc.contributor.authorShulkes, Arthuren
dc.contributor.authorBaldwin, Graham Sen
dc.date.accessioned2015-05-16T01:54:10Z
dc.date.available2015-05-16T01:54:10Z
dc.date.issued2014-03-01en
dc.identifier.citationBJU International; 113 Suppl 2(): 40-7en
dc.identifier.govdoc24894852en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12244en
dc.description.abstractGastrin-releasing peptide (GRP) acts as an important regulatory peptide in several normal physiological processes and as a growth factor in certain cancers. In this review we provide a comprehensive overview of the current state of knowledge of GRP in urological tissues under both normal and cancerous conditions. GRP and its receptor, GRP-R, are expressed in the normal kidney and renal cancers. GRP can stimulate the growth of renal cancer cells. GRP and GRP-R are expressed in prostate cancer and GRP can stimulate the growth of prostate cancer cell lines. Importantly, GRP is a key neuroendocrine peptide, which may be involved in the progression of advanced prostate cancer and in the neuroendocrine differentiation of prostate cancer. Recent animal studies have shown that GRP and GRP-R are an integral part of male sexual function and play a crucial role in spinal control of erections and ejaculation.en
dc.language.isoenen
dc.subject.otherbombesinen
dc.subject.othergastrin-releasing peptide (GRP)en
dc.subject.otherkidneyen
dc.subject.otherprostateen
dc.subject.otherprostate canceren
dc.subject.otherrenal canceren
dc.subject.othersexual functionen
dc.subject.otherAnimalsen
dc.subject.otherCarcinoma, Renal Cell.metabolism.physiopathologyen
dc.subject.otherCell Line, Tumoren
dc.subject.otherCoitusen
dc.subject.otherDisease Progressionen
dc.subject.otherDogsen
dc.subject.otherEjaculationen
dc.subject.otherGastrin-Releasing Peptide.genetics.metabolismen
dc.subject.otherGene Expression Regulation, Neoplasticen
dc.subject.otherHumansen
dc.subject.otherKidney Neoplasms.metabolism.physiopathologyen
dc.subject.otherMaleen
dc.subject.otherProstate.metabolismen
dc.subject.otherProstatic Neoplasms.metabolism.physiopathologyen
dc.subject.otherRatsen
dc.subject.otherReceptors, Bombesin.genetics.metabolismen
dc.subject.otherSynaptic Transmissionen
dc.titleExpression and function of gastrin-releasing peptide (GRP) in normal and cancerous urological tissues.en
dc.typeJournal Articleen
dc.identifier.journaltitleBJU Internationalen
dc.identifier.affiliationDepartment of Urology, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia, Australiaen
dc.identifier.affiliationDepartment of Surgery, Austin Health, Heidelberg, Victoria, Australia, Australiaen
dc.identifier.doi10.1111/bju.12594en
dc.description.pages40-7en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/24894852en
dc.type.austinJournal Articleen
local.name.researcherBolton, Damien M
item.grantfulltextnone-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.deptUrology-
crisitem.author.deptUrology-
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