Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/12159
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Amarenco, Pierre | en |
dc.contributor.author | Davis, Stephen M | en |
dc.contributor.author | Jones, Elizabeth F | en |
dc.contributor.author | Cohen, Ariel A | en |
dc.contributor.author | Heiss, Wolf-Dieter | en |
dc.contributor.author | Kaste, Markku | en |
dc.contributor.author | Laouénan, Cédric | en |
dc.contributor.author | Young, Dennis | en |
dc.contributor.author | Macleod, Malcolm R | en |
dc.contributor.author | Donnan, Geoffrey A | en |
dc.date.accessioned | 2015-05-16T01:48:37Z | |
dc.date.available | 2015-05-16T01:48:37Z | |
dc.date.issued | 2014-04-03 | en |
dc.identifier.citation | Stroke; A Journal of Cerebral Circulation 2014; 45(5): 1248-57 | en |
dc.identifier.govdoc | 24699050 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/12159 | en |
dc.description.abstract | Severe atherosclerosis in the aortic arch is associated with a high risk of recurrent vascular events, but the optimal antithrombotic strategy is unclear.This prospective randomized controlled, open-labeled trial, with blinded end point evaluation (PROBE design) tested superiority of aspirin 75 to 150 mg/d plus clopidogrel 75 mg/d (A+C) over warfarin therapy (international normalized ratio 2-3) in patients with ischemic stroke, transient ischemic attack, or peripheral embolism with plaque in the thoracic aorta>4 mm and no other identified embolic source. The primary end point included cerebral infarction, myocardial infarction, peripheral embolism, vascular death, or intracranial hemorrhage. Follow-up visits occurred at 1 month and then every 4 months post randomization.The trial was stopped after 349 patients were randomized during a period of 8 years and 3 months. After a median follow-up of 3.4 years, the primary end point occurred in 7.6% (13/172) and 11.3% (20/177) of patients on A+C and on warfarin, respectively (log-rank, P=0.2). The adjusted hazard ratio was 0.76 (95% confidence interval, 0.36-1.61; P=0.5). Major hemorrhages including intracranial hemorrhages occurred in 4 and 6 patients in the A+C and warfarin groups, respectively. Vascular deaths occurred in 0 patients in A+C arm compared with 6 (3.4%) patients in the warfarin arm (log-rank, P=0.013). Time in therapeutic range (67% of the time for international normalized ratio 2-3) analysis by tertiles showed no significant differences across groups.Because of lack of power, this trial was inconclusive and results should be taken as hypothesis generating.http://www.clinicaltrials.gov. Unique identifier: NCT00235248. | en |
dc.language.iso | en | en |
dc.subject.other | aorta | en |
dc.subject.other | atherosclerosis | en |
dc.subject.other | cerebral infarction | en |
dc.subject.other | Aged | en |
dc.subject.other | Aged, 80 and over | en |
dc.subject.other | Anticoagulants.administration & dosage.pharmacology | en |
dc.subject.other | Aorta, Thoracic.pathology | en |
dc.subject.other | Aortic Diseases.drug therapy.epidemiology.mortality | en |
dc.subject.other | Aspirin.administration & dosage.pharmacology | en |
dc.subject.other | Brain Ischemia.drug therapy.epidemiology.mortality | en |
dc.subject.other | Drug Therapy, Combination | en |
dc.subject.other | Embolism.drug therapy.epidemiology.mortality | en |
dc.subject.other | Female | en |
dc.subject.other | Humans | en |
dc.subject.other | Male | en |
dc.subject.other | Middle Aged | en |
dc.subject.other | Plaque, Atherosclerotic.drug therapy.epidemiology.mortality | en |
dc.subject.other | Platelet Aggregation Inhibitors.administration & dosage.pharmacology | en |
dc.subject.other | Prospective Studies | en |
dc.subject.other | Single-Blind Method | en |
dc.subject.other | Stroke.drug therapy.epidemiology.mortality | en |
dc.subject.other | Ticlopidine.administration & dosage.analogs & derivatives.pharmacology | en |
dc.subject.other | Treatment Outcome | en |
dc.subject.other | Warfarin.administration & dosage.pharmacology | en |
dc.title | Clopidogrel plus aspirin versus warfarin in patients with stroke and aortic arch plaques. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Stroke | en |
dc.identifier.affiliation | Department of Cardiology, Austin Health, Heidelberg, Victoria, Australia (E.F.J.); Max Planck Institute for Neurological Research, Cologne, Germany (W.-D.H.); Department of Neurology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland (M.K.); Stroke and Ageing Research Centre, Monash University, Melbourne, Australia (D.Y.); and Division of Clinical Neurosciences, University of Edinburgh (SC005336), Scotland, United Kingdom (M.M.). | en |
dc.identifier.affiliation | Department of Neurology, Royal Melbourne Hospital (S.D.) and Florey Institute of Neuroscience and Mental Health (D.Y., M.M., G.A.D.), University of Melbourne, Melbourne, Australia | en |
dc.identifier.affiliation | From the Department of Neurology, Stroke Centre, DHU FIRE, INSERM U 1148, Paris Diderot-Sorbonne University, Hôpital Bichat (P.A.), Department of Cardiology, Saint-Antoine Hospital and Medical School, Univeristé Pierre et Marie Curie (A.A.C.), and Department of Biostatistics, Paris-Diderot-Sorbonne University, Hôpital Bichat (C.L.), Assistance Publique-Hôpitaux de Paris, Paris, France | en |
dc.identifier.doi | 10.1161/STROKEAHA.113.004251 | en |
dc.description.pages | 1248-57 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/24699050 | en |
dc.contributor.corpauthor | Aortic Arch Related Cerebral Hazard Trial Investigators | en |
dc.type.austin | Journal Article | en |
local.name.researcher | Donnan, Geoffrey A | |
item.languageiso639-1 | en | - |
item.openairetype | Journal Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Cardiology | - |
crisitem.author.dept | The Florey Institute of Neuroscience and Mental Health | - |
Appears in Collections: | Journal articles |
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.