Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12128
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dc.contributor.authorKaukonen, Kirsi-Maijaen
dc.contributor.authorBailey, Michael Jen
dc.contributor.authorSuzuki, Satoshien
dc.contributor.authorPilcher, David Ven
dc.contributor.authorBellomo, Rinaldoen
dc.date.accessioned2015-05-16T01:46:40Z
dc.date.available2015-05-16T01:46:40Z
dc.date.issued2014-04-02en
dc.identifier.citationJama; 311(13): 1308-16en
dc.identifier.govdoc24638143en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12128en
dc.description.abstractSevere sepsis and septic shock are major causes of mortality in intensive care unit (ICU) patients. It is unknown whether progress has been made in decreasing their mortality rate.To describe changes in mortality for severe sepsis with and without shock in ICU patients.Retrospective, observational study from 2000 to 2012 including 101,064 patients with severe sepsis from 171 ICUs with various patient case mix in Australia and New Zealand.Hospital outcome (mortality and discharge to home, to other hospital, or to rehabilitation).Absolute mortality in severe sepsis decreased from 35.0% (95% CI, 33.2%-36.8%; 949/2708) to 18.4% (95% CI, 17.8%-19.0%; 2300/12,512; P < .001), representing an overall decrease of 16.7% (95% CI, 14.8%-18.6%), an annual rate of absolute decrease of 1.3%, and a relative risk reduction of 47.5% (95% CI, 44.1%-50.8%). After adjusted analysis, mortality decreased throughout the study period with an odds ratio (OR) of 0.49 (95% CI, 0.46-0.52) in 2012, using the year 2000 as the reference (P < .001). The annual decline in mortality did not differ significantly between patients with severe sepsis and those with all other diagnoses (OR, 0.94 [95% CI, 0.94-0.95] vs 0.94 [95% CI, 0.94-0.94]; P = .37). The annual increase in rates of discharge to home was significantly greater in patients with severe sepsis compared with all other diagnoses (OR, 1.03 [95% CI, 1.02-1.03] vs 1.01 [95% CI, 1.01-1.01]; P < .001). Conversely, the annual increase in the rate of patients discharged to rehabilitation facilities was significantly less in severe sepsis compared with all other diagnoses (OR, 1.08 [95% CI, 1.07-1.09] vs 1.09 [95% CI, 1.09-1.10]; P < .001). In the absence of comorbidities and older age, mortality was less than 5%.In critically ill patients in Australia and New Zealand with severe sepsis with and without shock, there was a decrease in mortality from 2000 to 2012. These findings were accompanied by changes in the patterns of discharge to home, rehabilitation, and other hospitals.en
dc.language.isoenen
dc.subject.otherAgeden
dc.subject.otherAustraliaen
dc.subject.otherCritical Illness.mortalityen
dc.subject.otherFemaleen
dc.subject.otherHospital Mortality.trendsen
dc.subject.otherHumansen
dc.subject.otherIntensive Care Units.statistics & numerical dataen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherNew Zealanden
dc.subject.otherPatient Discharge.trendsen
dc.subject.otherRetrospective Studiesen
dc.subject.otherSepsis.mortalityen
dc.subject.otherShock, Septic.mortalityen
dc.titleMortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012.en
dc.typeJournal Articleen
dc.identifier.journaltitleJAMAen
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre (ANZIC RC), Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia3Intensive Care Unit, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationIntensive Care Unit, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre (ANZIC RC), Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australiaen
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre (ANZIC RC), Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia2Critical Care Research Group, Intensive Care Unit, Helsinki University Central Hospital, Hels.en
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre (ANZIC RC), Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia4ANZICS Centre for Outcome and Resource Evaluation CORE, Melbourne, Australia5Department of In.en
dc.identifier.doi10.1001/jama.2014.2637en
dc.description.pages1308-16en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/24638143en
dc.type.austinJournal Articleen
local.name.researcherBellomo, Rinaldo
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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