Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12123
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dc.contributor.authorYates, Paul A-
dc.contributor.authorDesmond, Patricia M-
dc.contributor.authorPhal, Pramit M-
dc.contributor.authorSteward, Christopher-
dc.contributor.authorSzoeke, Cassandra-
dc.contributor.authorSalvado, Olivier-
dc.contributor.authorEllis, Kathryn A-
dc.contributor.authorMartins, Ralph N-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorAmes, David-
dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorRowe, Christopher C-
dc.date.accessioned2015-05-16T01:46:20Z
dc.date.available2015-05-16T01:46:20Z
dc.date.issued2014-03-12-
dc.identifier.citationNeurology 2014; 82(14): 1266-73en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12123en
dc.description.abstractWe sought to determine the incidence and associations of lobar microbleeds (LMBs) in a longitudinal cohort with (11)C-Pittsburgh compound B (PiB) PET imaging.One hundred seventy-four participants from the observational Australian Imaging, Biomarkers and Lifestyle Study of Ageing (97 with normal cognition [NC], 37 with mild cognitive impairment [MCI], and 40 with Alzheimer disease [AD] dementia) were assessed at 3 time points over 3 years with 3-tesla susceptibility-weighted MRI and (11)C-PiB PET. MRIs were inspected for microbleeds, siderosis, infarction, and white matter hyperintensity severity, blind to clinical and PiB findings. Neocortical PiB standardized uptake value ratio, normalized to cerebellar cortex, was dichotomized as positive or negative (PiB+/-, standardized uptake value ratio >1.5). Annualized LMB incidence was calculated, and logistic regression was used to determine the association of incident LMBs with PiB, APOE ε4+ status, and cerebrovascular disease.LMBs were present in 18.6% of NC, 24.3% of MCI, and 40% of AD participants (p < 0.05 vs NC). LMB incidence was 0.2 ± 0.6 per year in NC participants, 0.2 ± 0.5 in MCI, and 0.7 ± 1.4 in AD (p < 0.03 vs NC) and was 6-fold higher in PiB+ than PiB-NC. Incident LMBs were associated with age, APOE ε4+, PiB+, and baseline LMBs. Incidence of multiple LMBs was also associated with lacunar infarction and white matter hyperintensity severity.Older age, baseline LMBs, higher β-amyloid burden, and concomitant cerebrovascular disease may all confer higher risk of incident LMBs. This should be considered when designing protocols for amyloid-modifying clinical trials.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAgeden
dc.subject.otherAged, 80 and overen
dc.subject.otherAlzheimer Disease.complications.radionuclide imagingen
dc.subject.otherAmyloid.metabolismen
dc.subject.otherAniline Compounds.diagnostic useen
dc.subject.otherAustraliaen
dc.subject.otherBrain.pathology.radionuclide imagingen
dc.subject.otherCerebral Small Vessel Diseases.complications.diagnosisen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherIncidenceen
dc.subject.otherIntracranial Hemorrhages.complications.epidemiology.radionuclide imagingen
dc.subject.otherMagnetic Resonance Imaging.methodsen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherPositron-Emission Tomography.methodsen
dc.subject.otherThiazoles.diagnostic useen
dc.titleIncidence of cerebral microbleeds in preclinical Alzheimer disease.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeurologyen
dc.identifier.affiliationFrom the Department of Nuclear Medicine and Centre for PET (P.A.Y., V.L.V., C.C.R.), Austin Health, Heidelberg; The University of Melbourne (P.A.Y., P.M.D., C.S., C.C.R.), Parkville; Department of Radiology (P.M.D., P.M.P., C.S.), Royal Melbourne Hospital, Parkville; National Ageing Research Institute (D.A.), Parkville; CSIRO Preventative Health Flagship (O.S.), Parkville; Florey Institute of Neuroscience and Mental Health (K.A.E., C.L.M., V.L.V.), The University of Melbourne, Parkville; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, Kew, Victoria; Centre of Excellence for Alzheimer's Disease Research and Care (R.N.M.), School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Australiaen
dc.identifier.doi10.1212/WNL.0000000000000285en
dc.description.pages1266-73en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/24623839en
dc.contributor.corpauthorAIBL Research Groupen
dc.type.contentTexten
dc.type.austinJournal Articleen
local.name.researcherMasters, Colin L
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptAged Care-
crisitem.author.deptGeriatric Medicine-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMolecular Imaging and Therapy-
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