Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12104
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dc.contributor.authorBellomo, Rinaldoen
dc.contributor.authorCass, Alanen
dc.contributor.authorCole, Louiseen
dc.contributor.authorFinfer, Simonen
dc.contributor.authorGallagher, Martinen
dc.contributor.authorKim, In Byungen
dc.contributor.authorLee, Joanneen
dc.contributor.authorLo, Serigneen
dc.contributor.authorMcArthur, Colin Jen
dc.contributor.authorMcGuinness, Shayen
dc.contributor.authorMcGuiness, Shayen
dc.contributor.authorNorton, Robynen
dc.contributor.authorMyburgh, Johnen
dc.contributor.authorScheinkestel, Carlosen
dc.date.accessioned2015-05-16T01:45:07Z
dc.date.available2015-05-16T01:45:07Z
dc.date.issued2014-03-01en
dc.identifier.citationCritical Care and Resuscitation; 16(1): 34-41en
dc.identifier.govdoc24588434en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12104en
dc.description.abstractTo identify risk factors for development of hypophosphataemia in patients treated with two different intensities of continuous renal replacement therapy (CRRT) and to assess the independent association of hypophosphataemia with major clinical outcomes.We performed secondary analysis of data collected from 1441 patients during a large, multicentre randomised controlled trial of CRRT intensity. We allocated patients to two different intensities of CRRT (25mL/kg/hour vs 40 mL/kg/hour of effluent generation) and obtained daily measurement of serum phosphate levels.We obtained 14 115 phosphate measurements and identified 462 patients (32.1%) with hypophosphataemia, with peak incidence on Day 2 and Day 3. With lower intensity CRRT, there were 58 episodes of hypophosphataemia/1000 patient days, compared with 112 episodes/1000 patient days with higher intensity CRRT (P < 0.001). On multivariable logistic regression analysis, higher intensity CRRT, female sex, higher Acute Physiology and Chronic Health Evaluation score and hypokalaemia were independently associated with an increased odds ratio (OR) for hypophosphataemia. On multivariable models, hypophosphataemia was associated with better clinical outcomes, but when analysis was confined to patients alive at 96 hours, hypophosphataemia was not independently associated with clinical outcomes.Hypophosphataemia is common during CRRT and its incidence increases with greater CRRT intensity. Hypophosphataemia is not a robust independent predictor of mortality. Its greater incidence in the higher intensity CRRT arm of the Randomised Evaluation of Normal vs Augmented Level trial does not explain the lack of improved outcomes with such treatment.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAustralia.epidemiologyen
dc.subject.otherCritical Illness.therapyen
dc.subject.otherFemaleen
dc.subject.otherFollow-Up Studiesen
dc.subject.otherHumansen
dc.subject.otherHypophosphatemia.blood.epidemiology.etiologyen
dc.subject.otherIncidenceen
dc.subject.otherMaleen
dc.subject.otherNew Zealand.epidemiologyen
dc.subject.otherPhosphates.blooden
dc.subject.otherPrognosisen
dc.subject.otherRenal Replacement Therapy.methodsen
dc.subject.otherRetrospective Studiesen
dc.subject.otherSurvival Rate.trendsen
dc.titleThe relationship between hypophosphataemia and outcomes during low-intensity and high-intensity continuous renal replacement therapy.en
dc.typeJournal Articleen
dc.identifier.journaltitleCritical Care and Resuscitationen
dc.identifier.affiliationIntensive Care Unit, Nepean Hospital, Sydney, NSW, Australiaen
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, Melbourne, Victoria, Australiaen
dc.identifier.affiliationIntensive Care Department, Royal North Shore Hospital, Sydney, NSW, Australiaen
dc.identifier.affiliationIntensive Care Unit, Austin Hospital, Melbourne, Victoria, Australiaen
dc.identifier.affiliationMenzies School of Health Research, Charles Darwin University, Darwin, NT, Australiaen
dc.identifier.affiliationThe George Institute for Global Health, Sydney, NSW, Australiaen
dc.identifier.affiliationDepartment of Intensive Care, Alfred Hospital, Melbourne, Victoria, Australiaen
dc.identifier.affiliationAuckland City Hospital, Auckland, New Zealand.en
dc.description.pages34-41en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/24588434en
dc.type.austinJournal Articleen
local.name.researcherBellomo, Rinaldo
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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