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dc.contributor.authorHowell, Jessica-
dc.contributor.authorGow, Paul J-
dc.contributor.authorAngus, Peter W-
dc.contributor.authorVisvanathan, Kumar-
dc.identifier.citationLiver Transplantation : Official Publication of the American Association For the Study of Liver Diseases and the International Liver Transplantation Society 2014; 20(3): 270-80en_US
dc.description.abstractToll-like receptors (TLRs) are pathogen recognition receptors that orchestrate the innate immune response and the subsequent adaptive immune response. TLRs can be triggered by exogenous ligands expressed by invading pathogens or by the release of endogenous ligands, such as that occurring through cellular injury during the transplantation process. They are now recognized to play an important role in many facets of transplantation biology, including rejection and tolerance, ischemia/reperfusion injury (IRI), and infections after transplantation. The role of TLRs in liver transplantation is unique with respect to other organ transplants because the portal circulation is a continuous source of TLR2 and TLR4 ligands, and this influences TLR signaling pathways, which have a central role in transplantation immunity. This review provides a critical update on recent data outlining the important role of TLRs in liver transplantation, and there is a particular focus on emerging advances in our understanding of rejection and tolerance, IRI, and infections after transplantation and on the ways in which these events may influence the recurrence of diseases such as hepatitis C infection after liver transplantation.en_US
dc.subject.otherAdaptive Immunityen
dc.subject.otherGraft Rejection.prevention & controlen
dc.subject.otherGraft Survivalen
dc.subject.otherHepatitis C.prevention & controlen
dc.subject.otherImmunity, Innateen
dc.subject.otherLiver Failure.metabolism.surgeryen
dc.subject.otherLiver Transplantationen
dc.subject.otherReperfusion Injury.prevention & controlen
dc.subject.otherSignal Transductionen
dc.subject.otherToll-Like Receptor 4.physiologyen
dc.subject.otherToll-Like Receptors.physiologyen
dc.subject.otherTransplantation Toleranceen
dc.titleRole of toll-like receptors in liver transplantation.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleLiver Transplantation : Official Publication of the American Association For the Study of Liver Diseases and the International Liver Transplantation Societyen_US
dc.identifier.affiliationVictorian Liver Transplant Uniten_US
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Melbourne, Australiaen_US
dc.type.austinJournal Articleen, Peter W
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristype Liver Transplant Unit- and Hepatology- Liver Transplant Unit- and Hepatology-
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