Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11870
Full metadata record
DC FieldValueLanguage
dc.contributor.authorHowell, Jessica-
dc.contributor.authorSawhney, R-
dc.contributor.authorAngus, Peter W-
dc.contributor.authorFink, M-
dc.contributor.authorJones, R-
dc.contributor.authorWang, B Z-
dc.contributor.authorVisvanathan, K-
dc.contributor.authorCrowley, Peter-
dc.contributor.authorGow, Paul J-
dc.date.accessioned2015-05-16T01:30:02Z
dc.date.available2015-05-16T01:30:02Z
dc.date.issued2013-09-13-
dc.identifier.citationTransplant Infectious Disease : An Official Journal of the Transplantation Society 2013; 15(6): 588-99en_US
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11870en
dc.description.abstractHepatitis C virus (HCV) recurrence post liver transplant is universal, with a subgroup of patients developing rapid hepatic fibrosis. Various clinical definitions of rapid fibrosis (RF) have been used to identify risks for rapid progression, but their comparability and efficacy at predicting adverse outcomes has not been determined.Retrospective data analysis was conducted on 100 adult patients with HCV who underwent liver transplantation at a single center. We measured year 1 fibrosis progression (RF defined as METAVIR F score ≥ 1 at 1-year liver biopsy), time to METAVIR F2-stage fibrosis, and fibrosis rate (calculated using liver biopsies graded by METAVIR scoring F0-4; fibrosis rate = fibrosis stage/year post transplant). RF was defined as ≥ 0.5 units/year.Multivariate analysis revealed that donor age and peak HCV viral load were significant risks for RF, when fibrosis rate was used to define RF. Advanced donor age was a risk for rapid progression to F2-stage fibrosis, whereas genotype 2 or 3 HCV infection was protective. Fibrosis rate had the strongest correlation with time to cirrhosis development (P < 0.0001, r = -0.76) and was the most accurate predictor of rapid graft cirrhosis (P < 0.0001, area under the curve 0.979, sensitivity 100%, specificity 94%).Different measures of RF progression identify different risks for RF and are not directly comparable. Fibrosis rate was the most accurate predictor of rapid graft cirrhosis.en_US
dc.language.isoenen
dc.subject.otherhepatitis Cen
dc.subject.otherliver cirrhosisen
dc.subject.otherliver fibrosisen
dc.subject.otherliver transplantationen
dc.subject.otherrapid fibrosis progressionen
dc.subject.otherAdulten
dc.subject.otherAge Factorsen
dc.subject.otherArea Under Curveen
dc.subject.otherBiopsyen
dc.subject.otherDisease Progressionen
dc.subject.otherFemaleen
dc.subject.otherFibrosisen
dc.subject.otherGenotypeen
dc.subject.otherHepacivirus.geneticsen
dc.subject.otherHepatitis C, Chronic.pathology.surgeryen
dc.subject.otherHumansen
dc.subject.otherLiver.pathologyen
dc.subject.otherLiver Cirrhosis.pathology.virologyen
dc.subject.otherLiver Transplantationen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherROC Curveen
dc.subject.otherRecurrenceen
dc.subject.otherRetrospective Studiesen
dc.subject.otherRisk Factorsen
dc.subject.otherSeverity of Illness Indexen
dc.subject.otherTime Factorsen
dc.subject.otherViral Loaden
dc.titleIdentifying the superior measure of rapid fibrosis for predicting premature cirrhosis after liver transplantation for hepatitis C.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleTransplant Infectious Disease : an Official Journal of the Transplantation Societyen_US
dc.identifier.affiliationVictorian Liver Transplant Uniten_US
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Melbourne, Victoria, Australiaen_US
dc.identifier.doi10.1111/tid.12134en_US
dc.description.pages588-99en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/24028328en
dc.type.contentTexten_US
dc.type.austinJournal Articleen
local.name.researcherAngus, Peter W
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptSurgery-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptSurgery (University of Melbourne)-
crisitem.author.deptHepatopancreatobiliary Surgery-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

24
checked on Mar 28, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.