Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11844
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dc.contributor.authorTebbutt, Niall Cen
dc.contributor.authorPedersen, Mikkel Wen
dc.contributor.authorJohns, Terrance Gen
dc.date.accessioned2015-05-16T01:28:24Z
dc.date.available2015-05-16T01:28:24Z
dc.date.issued2013-08-16en
dc.identifier.citationNature Reviews. Cancer 2013; 13(9): 663-73en
dc.identifier.govdoc23949426en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/11844en
dc.description.abstractThe ERBB family of receptor tyrosine kinases has a central role in the tumorigenesis of many types of solid tumour. Various therapeutics targeting these receptors have been approved for the treatment of several cancers. Considerable preclinical data have shown that the administration of two inhibitors against an individual ERBB family member--particularly epidermal growth factor receptor (EGFR) or ERBB2--leads to markedly higher antitumour activity than the administration of single agents. This Opinion article describes the preclinical and clinical performance of these dual-targeting approaches, discusses the key mechanisms that mediate their increased efficacy and highlights areas for ongoing investigation.en
dc.language.isoenen
dc.subject.otherAntibodies, Monoclonal.administration & dosage.pharmacologyen
dc.subject.otherAntineoplastic Combined Chemotherapy Protocols.therapeutic useen
dc.subject.otherDrug Resistance, Neoplasmen
dc.subject.otherHumansen
dc.subject.otherNeoplasms.drug therapy.enzymologyen
dc.subject.otherProtein Kinase Inhibitors.administration & dosage.pharmacologyen
dc.subject.otherReceptor, Epidermal Growth Factor.antagonists & inhibitors.immunology.metabolismen
dc.subject.otherReceptor, ErbB-2.antagonists & inhibitors.immunology.metabolismen
dc.titleTargeting the ERBB family in cancer: couples therapy.en
dc.typeJournal Articleen
dc.identifier.journaltitleNature reviews. Canceren
dc.identifier.affiliationLudwig Oncology Unit, Austin Health, Studley Road, Heidelberg, Victoria 3084, Australiaen
dc.identifier.doi10.1038/nrc3559en
dc.description.pages663-73en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/23949426en
dc.type.austinJournal Articleen
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptMedical Oncology-
crisitem.author.deptOlivia Newton-John Cancer Wellness and Research Centre-
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