Austin Health

Advances in chronic obstructive pulmonary disease.

Author(s)
McDonald, Christine F
Khor, Yet H
Publication Date
2013-08-01
Abstract
Chronic obstructive pulmonary disease (COPD) is characterised by progressive airflow limitation in the presence of identifiable risk factors. Inflammation is the central pathological feature in the pathogenesis of COPD. In addition to its pulmonary effects, COPD is associated with significant extrapulmonary manifestations, including ischaemic heart disease, osteoporosis, stroke and diabetes. Anxiety and depression are also common. Spirometry remains the gold standard diagnostic tool. Pharmacologic and non-pharmacologic therapy can improve symptoms, quality of life and exercise capacity and, through their effects on reducing exacerbations, have the potential to modify disease progression. Bronchodilators are the mainstay of pharmacotherapy, with guidelines recommending a stepwise escalating approach. Smoking cessation is paramount in managing COPD, with promotion of physical activity and pulmonary rehabilitation being other key factors in management. Comorbidities should be actively sought and managed in their own right. Given the chronicity and progressive nature of COPD, ongoing monitoring and support with timely discussion of advanced-care planning and end-of-life issues are recommended.
Citation
Internal Medicine Journal; 43(8): 854-862
Jornal Title
Internal Medicine Journal
OrcId
0000-0002-5434-9342
0000-0001-6481-3391
Link
Title
Advances in chronic obstructive pulmonary disease.
Type of document
Journal Article

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