Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11817
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dc.contributor.authorFlanagan, Den
dc.contributor.authorBadawy, Radwa A Ben
dc.contributor.authorJackson, Graeme Den
dc.date.accessioned2015-05-16T01:26:44Z-
dc.date.available2015-05-16T01:26:44Z-
dc.date.issued2013-07-17en
dc.identifier.citationClinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology 2013; 125(1): 21-31en
dc.identifier.govdoc23871167en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/11817en
dc.description.abstractTo identify features of BOLD signal change associated with interictal epileptiform discharges (IEDs) in a heterogeneous group of focal epilepsy patients.EEG/fMRI studies in 27 focal epilepsy patients were reviewed with attention given to the extent and location of the IED and the resulting pattern of BOLD signal change. Second order group analysis was used to identify common features.fMRI results provided novel clinical information for individual patients. We identified a significant common node within the ipsilateral piriform cortex as well as patterns involving distant cortical or subcortical areas.Despite the heterogeneity of IEDs in focal epilepsy, there are important common features underpining IEDs with a highly significant fMRI node in the ipsilateral piriform cortex.There are important common features in the networks involved in IEDs in patients with a heterogeneous range of epileptogenic foci. We confirm that the piriform cortex is a common node underlying IEDs in patients with focal epilepsy and so provides a target for further study and potential therapy. We describe important features of BOLD signal change that accompany focal and diffuse IEDs that will help researchers and clinicians navigate the sometimes complex findings revealed by these studies.en
dc.language.isoenen
dc.subject.otherEEG–fMRIen
dc.subject.otherFocal epilepsyen
dc.subject.otherIEDen
dc.subject.otherPiriform cortexen
dc.subject.otherAdolescenten
dc.subject.otherAdulten
dc.subject.otherBrain.physiopathologyen
dc.subject.otherChilden
dc.subject.otherElectroencephalography.methodsen
dc.subject.otherEpilepsies, Partial.physiopathologyen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherMagnetic Resonance Imaging.methodsen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherNerve Net.physiologyen
dc.subject.otherYoung Adulten
dc.titleEEG-fMRI in focal epilepsy: local activation and regional networks.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiologyen
dc.identifier.affiliationBrain Research Institute, The Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationDepartment of Neurology, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationEpilepsy Research Centre, Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1016/j.clinph.2013.06.182en
dc.description.pages21-31en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/23871167en
dc.type.austinJournal Articleen
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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