Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11805
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dc.contributor.authorBolton, Damien Men
dc.contributor.authorTa, Aen
dc.contributor.authorBagnato, Men
dc.contributor.authorMuller, Den
dc.contributor.authorLawrentschuk, Nathanen
dc.contributor.authorSeveri, Gen
dc.contributor.authorSyme, R Ren
dc.contributor.authorGiles, Graham Gen
dc.date.accessioned2015-05-16T01:26:00Z
dc.date.available2015-05-16T01:26:00Z
dc.date.issued2013-07-04en
dc.identifier.citationWorld Journal of Urology 2013; 32(2): 431-5en
dc.identifier.govdoc23824175en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11805en
dc.description.abstractTo evaluate the temporal relationship between interval to biochemical recurrence (BCR) following radical prostatectomy (RP) and prostate cancer-specific mortality (PCSM).The study comprised of 2,116 men from the Victorian Radical Prostatectomy Register, a whole-of-population database of all RPs performed between 1995 and 2000 in Victoria, Australia. Follow-up prostate-specific antigen and death data were obtained via record linkage to pathology laboratories and the Victorian Registry of Births, Deaths and Marriages. Poisson regression models with PCSM as the outcome were fit to the data. Models included age at surgery, Gleason score and tumour stage as covariates.Median post-surgery and post-BCR follow-up was 10.3 and 7.5 years, respectively. 695 men (33 %) experienced BCR during follow-up, of which 82 % occurred within 5 years of RP; 66 men died from prostate cancer. Men with combined high Gleason sum (≥4 + 3) and extra-prostatic (≥pT3a) disease had substantially increased mortality rate with early BCR, while those experiencing BCR after a longer interval had significantly lower mortality. Men with combined low Gleason sum (≤3 + 4) and organ-confined disease (≤pT2c) risk disease were not at any substantial risk of death in this time frame regardless of timing of BCR following RP.This study evaluates the temporal relationship between BCR and PCSM using a whole-of-population cohort of men treated with RP. Men with low-risk features of prostate cancer at time of RP have low mortality even if they experience early BCR. This subgroup may be counselled regarding their favourable long-term prognosis.en
dc.language.isoenen
dc.subject.otherAgeden
dc.subject.otherCohort Studiesen
dc.subject.otherDatabases, Factualen
dc.subject.otherDisease-Free Survivalen
dc.subject.otherHumansen
dc.subject.otherKallikreins.blooden
dc.subject.otherMaleen
dc.subject.otherMedical Record Linkageen
dc.subject.otherMiddle Ageden
dc.subject.otherNeoplasm Gradingen
dc.subject.otherNeoplasm Recurrence, Local.blooden
dc.subject.otherProstate.pathologyen
dc.subject.otherProstate-Specific Antigen.blooden
dc.subject.otherProstatectomyen
dc.subject.otherProstatic Neoplasms.blood.mortality.surgeryen
dc.subject.otherRetrospective Studiesen
dc.subject.otherRisken
dc.subject.otherSurvival Rateen
dc.subject.otherTime Factorsen
dc.subject.otherVictoriaen
dc.titleInterval to biochemical recurrence following radical prostatectomy does not affect survival in men with low-risk prostate cancer.en
dc.typeJournal Articleen
dc.identifier.journaltitleWorld Journal of Urologyen
dc.identifier.affiliationAustin Health, Heidelberg, VIC, Australia,en
dc.identifier.doi10.1007/s00345-013-1125-0en
dc.description.pages431-5en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/23824175en
dc.type.austinJournal Articleen
local.name.researcherBolton, Damien M
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptUrology-
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