Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11767
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dc.contributor.authorChua, Horng-Rueyen
dc.contributor.authorSchneider, Antoine Gen
dc.contributor.authorBaldwin, Ian Cen
dc.contributor.authorCollins, Allison Len
dc.contributor.authorHo, Lisaen
dc.contributor.authorBellomo, Rinaldoen
dc.date.accessioned2015-05-16T01:23:41Z
dc.date.available2015-05-16T01:23:41Z
dc.date.issued2013-05-14en
dc.identifier.citationJournal of Critical Care 2013; 28(5): 884.e7-14en
dc.identifier.govdoc23683569en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11767en
dc.description.abstractThis study aimed to compare the biochemical effects of Phoxilium (containing phosphate at 1.2 mmol/L; Gambro Lundia AB, Lund, Sweden) and Hemosol-B0 (Gambro Lundia AB) as dialysate and/or replacement fluid during continuous renal replacement therapy (CRRT).We examined serum biochemistry in critically ill patients for 42 hours of Phoxilium administration for the prevention of hypophosphatemia during CRRT and compared them with corresponding results in random historical controls who received Hemosol-B0.We studied 15 patients in each arm (Phoxilium vs Hemosol-B0). Respective median ages were 57 (49-68) and 64 (57-67) years. Baseline patient illness severity scores, prescribed CRRT effluent rates, and cumulative phosphate intakes were comparable. After 36 to 42 hours of Phoxilium administration, serum phosphate levels increased from 0.95 (0.81-1.13) to 1.44 (1.23-1.78) mmol/L, in contrast to the decline from 1.71 (1.09-2.00) to 0.83 (0.55-1.59) mmol/L with Hemosol-B0 (P=.0001). Serum ionized calcium levels decreased from 1.27 (1.22-1.37) to 1.12 (1.06-1.21) mmol/L with Phoxilium, compared with an increase from 1.09 (0.90-1.19) to 1.20 (1.16-1.25) mmol/L with Hemosol-B0 (P<.0001). Serum bicarbonate, base excess levels, and effective strong ion difference decreased with Phoxilium and were lower than those with Hemosol-B0 at 36 to 42 hours (P<.05).Phoxilium effectively prevented hypophosphatemia during CRRT but was associated with relative metabolic acidosis and hypocalcemia compared with Hemosol-B0 use.en
dc.language.isoenen
dc.subject.otherAcid-base balanceen
dc.subject.otherAcute kidney injuryen
dc.subject.otherContinuous renal replacement therapyen
dc.subject.otherCritical illnessen
dc.subject.otherElectrolyte abnormalitiesen
dc.subject.otherHemosol-B0en
dc.subject.otherHyperphosphatemiaen
dc.subject.otherHypocalcemiaen
dc.subject.otherHypophosphatemiaen
dc.subject.otherMetabolic acidosisen
dc.subject.otherNutritionen
dc.subject.otherPhosphate-containing solutionen
dc.subject.otherPhoxiliumen
dc.subject.otherAcute Kidney Injury.therapyen
dc.subject.otherAgeden
dc.subject.otherBlood Substitutes.therapeutic useen
dc.subject.otherCase-Control Studiesen
dc.subject.otherCritical Illnessen
dc.subject.otherDialysis Solutions.therapeutic useen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherHypophosphatemia.prevention & controlen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherPhosphates.therapeutic useen
dc.subject.otherRenal Replacement Therapy.methodsen
dc.subject.otherRetrospective Studiesen
dc.subject.otherTreatment Outcomeen
dc.titlePhoxilium vs Hemosol-B0 for continuous renal replacement therapy in acute kidney injury.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Critical Careen
dc.identifier.affiliationDepartment of Intensive Care, Austin Hospital, Melbourne, Australiaen
dc.identifier.affiliationDivision of Nephrology, University Medicine Cluster, National University Hospital, National University Health System, Singapore.en
dc.identifier.doi10.1016/j.jcrc.2013.02.013en
dc.description.pages884.e7-14en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/23683569en
dc.type.austinJournal Articleen
local.name.researcherBaldwin, Ian C
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptInstitute for Breathing and Sleep-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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