Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11761
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dc.contributor.authorWeinberg, Laurenceen
dc.contributor.authorChang, Jen
dc.contributor.authorHayward, Philip A Ren
dc.contributor.authorReynolds, Men
dc.contributor.authorFernandes, Jen
dc.date.accessioned2015-05-16T01:23:18Z
dc.date.available2015-05-16T01:23:18Z
dc.date.issued2013-05-01en
dc.identifier.citationAnaesthesia and Intensive Care; 41(3): 386-9en
dc.identifier.govdoc23659403en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/11761en
dc.description.abstractWe report a case of thrombotic thrombocytopenic purpura in a woman post mitral valve repair who presented with unexplained thrombocytopenia, intermittent fever, acute renal failure and severe digital ischaemia. The diagnosis of thrombotic thrombocytopenic purpura was confirmed after exclusion of many of the aetiological factors of postoperative digital ischaemia, a positive haemolytic screen and blood film examination which showed schistocytes and fragmented red cells. Plasma ADAMTS-13 activity measured by enzyme-linked immunosorbent assay was reduced. Treatment of thrombotic thrombocytopenic purpura with exchange plasmapheresis and methylprednisolone was of paramount importance and the patient was discharged home on day 30 with complete recovery of haematological, neurological and renal function. In order to increase the awareness of this rare multisystem process, we report our experience in managing this life-threatening condition. Our discussion covers the diagnostic challenges, theories on aetiology, pathogenesis and treatment of this condition in the context of cardiac surgery.en
dc.language.isoenen
dc.subject.othercardiac surgeryen
dc.subject.otherthrombotic thrombocytopenic purpuraen
dc.subject.otherAgeden
dc.subject.otherAnti-Inflammatory Agents.therapeutic useen
dc.subject.otherCardiac Surgical Procedures.adverse effectsen
dc.subject.otherFemaleen
dc.subject.otherFingers.blood supplyen
dc.subject.otherHeart Valve Prosthesis Implantationen
dc.subject.otherHemofiltrationen
dc.subject.otherHumansen
dc.subject.otherIschemia.blood.etiology.therapyen
dc.subject.otherMethylprednisolone.therapeutic useen
dc.subject.otherMitral Valve Insufficiency.surgeryen
dc.subject.otherPlasmapheresisen
dc.subject.otherPostoperative Complications.blood.therapyen
dc.subject.otherPurpura, Thrombotic Thrombocytopenic.blood.etiology.therapyen
dc.subject.otherRegional Blood Flow.physiologyen
dc.titlePost-cardiac surgery thrombotic thrombocytopenic purpura with digital ischaemia.en
dc.typeJournal Articleen
dc.identifier.journaltitleAnaesthesia and Intensive Careen
dc.identifier.affiliationDepartment of Anaesthesia, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages386-9en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/23659403en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
crisitem.author.deptAnaesthesia-
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