Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11714
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dc.contributor.authorEckhaus, Jazminen
dc.contributor.authorLawrence, Kate Men
dc.contributor.authorHelbig, Ingoen
dc.contributor.authorBui, Minhen
dc.contributor.authorVadlamudi, Lataen
dc.contributor.authorHopper, John Len
dc.contributor.authorScheffer, Ingrid Een
dc.contributor.authorBerkovic, Samuel Fen
dc.date.accessioned2015-05-16T01:19:56Z
dc.date.available2015-05-16T01:19:56Z
dc.date.issued2013-03-21en
dc.identifier.citationEpilepsy Research 2013; 105(1-2): 103-9en
dc.identifier.govdoc23522981en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11714en
dc.description.abstractFebrile seizures (FS) are the most common seizure syndrome. A strong genetic component has been well established through family and twin studies; however, such studies have not examined the genetics of different FS types (simple, complex, febrile status epilepticus) and sub-syndromes (true FS, febrile seizures plus (FS+), 'FS with later epilepsy'). Here we used a community-based twin sample to analyze genetic factors within different FS subtypes and FS syndromes.Twin pairs were ascertained from the twin database of the Epilepsy Research Centre. A retrospective chart review was conducted and follow-up attempted for all subjects. Casewise concordance values were calculated for the different subgroups and intra-pair variation was analyzed.One hundred and seventy-nine twin pairs with FS were identified. Overall casewise concordance for FS in monozygotic (MZ) twins (0.62) was greater than in dizygotic (DZ) twins (0.16, p<0.0001). A greater concordance amongst MZ pairs than DZ twin pairs was also observed for all FS subtypes and FS sub-syndromes, particularly in twins with FS+. Within concordant MZ pairs, we did not observe the co-occurrence of FS and FS+.These results suggest a strong genetic contribution to different FS subtypes and sub-syndromes. They also support the existence of distinct genetic factors for different FS subtypes and sub-syndromes, especially FS+. This information is important for the strategic planning of next generation sequencing studies of febrile seizures.en
dc.language.isoenen
dc.subject.otherChilden
dc.subject.otherChild, Preschoolen
dc.subject.otherDiseases in Twins.diagnosis.epidemiology.geneticsen
dc.subject.otherFemaleen
dc.subject.otherFollow-Up Studiesen
dc.subject.otherHumansen
dc.subject.otherInfanten
dc.subject.otherMaleen
dc.subject.otherRegistriesen
dc.subject.otherRetrospective Studiesen
dc.subject.otherSeizures, Febrile.diagnosis.epidemiology.geneticsen
dc.subject.otherTwins, Dizygotic.geneticsen
dc.subject.otherTwins, Monozygotic.geneticsen
dc.titleGenetics of febrile seizure subtypes and syndromes: a twin study.en
dc.typeJournal Articleen
dc.identifier.journaltitleEpilepsy researchen
dc.identifier.affiliationEpilepsy Research Centre and Department of Medicine (Neurology), University of Melbourne, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1016/j.eplepsyres.2013.02.011en
dc.description.pages103-9en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/23522981en
dc.type.austinJournal Articleen
local.name.researcherBerkovic, Samuel F
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
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