Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/11679
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Howell, Jessica | - |
dc.contributor.author | Sawhney, R | - |
dc.contributor.author | Skinner, N | - |
dc.contributor.author | Gow, Paul J | - |
dc.contributor.author | Angus, Peter W | - |
dc.contributor.author | Ratnam, D | - |
dc.contributor.author | Visvanathan, K | - |
dc.date.accessioned | 2015-05-16T01:17:49Z | |
dc.date.available | 2015-05-16T01:17:49Z | |
dc.date.issued | 2013-02-20 | - |
dc.identifier.citation | American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2013; 13(4): 943-53 | en_US |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/11679 | en |
dc.description.abstract | Recurrence of hepatitis C (HCV) postliver transplant is universal, with a subgroup developing rapid hepatic fibrosis. Toll-like receptors (TLRs) are critical to innate antiviral responses and HCV alters TLR function to evade immune clearance. Whether TLRs play a role in rapid HCV recurrence posttransplant is unknown. We stimulated peripheral blood mononuclear cells (PBMCs) from 70 patients with HCV postliver transplant with TLR subclass-specific ligands and measured cytokine production, TLR expression and NK cell function. Rate of fibrosis progression was calculated using posttransplant liver biopsies graded by Metavir scoring (F0-4; R=fibrosis stage/year posttransplant; rapid fibrosis defined as >0.4 units/year). Thirty of 70 (43%) patients had rapid fibrosis progression. PBMCs from HCV rapid-fibrosers produced less IFNα with TLR7/8 stimulation (p=0.039), less IL-6 at baseline (p=0.027) and with TLR3 stimulation (p=0.008) and had lower TLR3-mediated monocyte IL-6 production (p=0.028) compared with HCV slow fibrosers. TLR7/8-mediated NKCD56 dim cell secretion of IFNγ was impaired in HCV rapid fibrosis (p=0.006) independently of IFNα secretion and TLR7/8 expression, while cytotoxicity remained preserved. Impaired TLR3 and TLR7/8-mediated cytokine responses may contribute to aggressive HCV recurrence postliver transplantation through impaired immune control of HCV and subsequent activation of fibrogenesis. | en_US |
dc.language.iso | en | en |
dc.subject.other | Adult | en |
dc.subject.other | Cross-Sectional Studies | en |
dc.subject.other | Cytokines.metabolism | en |
dc.subject.other | Disease Progression | en |
dc.subject.other | Female | en |
dc.subject.other | Hepacivirus | en |
dc.subject.other | Hepatitis C.metabolism.physiopathology | en |
dc.subject.other | Humans | en |
dc.subject.other | Interferon-alpha.metabolism | en |
dc.subject.other | Interferon-gamma.metabolism | en |
dc.subject.other | Interleukin-6.metabolism | en |
dc.subject.other | Killer Cells, Natural.cytology | en |
dc.subject.other | Leukocytes, Mononuclear.cytology | en |
dc.subject.other | Ligands | en |
dc.subject.other | Liver Cirrhosis.physiopathology.virology | en |
dc.subject.other | Liver Failure.therapy | en |
dc.subject.other | Liver Transplantation | en |
dc.subject.other | Male | en |
dc.subject.other | Middle Aged | en |
dc.subject.other | Prospective Studies | en |
dc.subject.other | Recurrence | en |
dc.subject.other | Toll-Like Receptor 3.metabolism | en |
dc.subject.other | Toll-Like Receptor 7.metabolism | en |
dc.subject.other | Toll-Like Receptor 8.metabolism | en |
dc.title | Toll-like receptor 3 and 7/8 function is impaired in hepatitis C rapid fibrosis progression post-liver transplantation. | en_US |
dc.type | Journal Article | en_US |
dc.identifier.journaltitle | American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons | en_US |
dc.identifier.affiliation | Medicine (University of Melbourne) | en_US |
dc.identifier.affiliation | Victorian Liver Transplant Unit | en_US |
dc.identifier.doi | 10.1111/ajt.12165 | en_US |
dc.description.pages | 943-53 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/23425350 | en |
dc.type.content | Text | en_US |
dc.type.austin | Journal Article | en |
local.name.researcher | Angus, Peter W | |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | Journal Article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Victorian Liver Transplant Unit | - |
crisitem.author.dept | Gastroenterology and Hepatology | - |
crisitem.author.dept | Victorian Liver Transplant Unit | - |
crisitem.author.dept | Gastroenterology and Hepatology | - |
Appears in Collections: | Journal articles |
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.