Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11668
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dc.contributor.authorConway, Elizabeth Len
dc.contributor.authorPhillips, P Aen
dc.contributor.authorDrummer, Olaf Hen
dc.contributor.authorLouis, William Jen
dc.date.accessioned2015-05-16T01:17:08Z
dc.date.available2015-05-16T01:17:08Z
dc.date.issued1990-03-01en
dc.identifier.citationJournal of Pharmaceutical Sciences; 79(3): 228-31en
dc.identifier.govdoc2338632en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/11668en
dc.description.abstractThe effects of food on the bioavailability of a sustained-release (SR) formulation of verapamil (SR-verapamil; Isoptin SR) were determined in an open, three-way single-dose study involving 12 volunteers receiving (in randomized order) the SR preparation (1 X 240 mg) either fasting or with food and a conventional formulation of verapamil (3 X 80 mg) fasting. Compared with the conventional formulation, SR-verapamil had a reduced Cmax, prolonged tmax, and unchanged t1/2, consistent with its SR formulation. The AUC was 80% of the conventional preparation. Concomitant food administration significantly prolonged the tmax of SR-verapamil from 7.3 +/- 3.4 to 11.7 +/- 6.3 h, but had little effect on Cmax, t1/2, or AUC. Similar results were obtained with the metabolite, norverapamil. Food administration also had little effect on the blood pressure and ECG effects of SR-verapamil. Cautions regarding taking this preparation with food therefore appear to be unnecessary.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAgeden
dc.subject.otherBiological Availabilityen
dc.subject.otherBlood Pressure.drug effectsen
dc.subject.otherChromatography, High Pressure Liquiden
dc.subject.otherDelayed-Action Preparationsen
dc.subject.otherElectrocardiographyen
dc.subject.otherFemaleen
dc.subject.otherFooden
dc.subject.otherHalf-Lifeen
dc.subject.otherHeart Rate.drug effectsen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherVerapamil.administration & dosage.analogs & derivatives.pharmacokinetics.pharmacologyen
dc.titleInfluence of food on the bioavailability of a sustained-release verapamil preparation.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of pharmaceutical sciencesen
dc.identifier.affiliationUniversity of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages228-31en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2338632en
dc.type.austinJournal Articleen
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptClinical Pharmacology and Therapeutics-
Appears in Collections:Journal articles
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