Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11643
Title: Siblings with refractory occipital epilepsy showing localized network activity on EEG-fMRI.
Austin Authors: Carney, Patrick W ;Harvey, A Simon;Berkovic, Samuel F ;Jackson, Graeme D ;Scheffer, Ingrid E 
Affiliation: Epilepsy Research Centre, Austin Health, Department of Medicine, University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: 7-Jan-2013
Publication information: Epilepsia 2013; 54(2): e28-32
Abstract: The benign occipital epilepsies of childhood include Panayiotopoulos and Gastaut syndromes; a third syndrome, idiopathic photosensitive occipital epilepsy may also begin in childhood or adolescence. We describe siblings with occipital epilepsy characterized by refractory, frequent, brief visual seizures and normal magnetic resonance imaging (MRI). Electroencephalography (EEG) with functional MRI (fMRI) supports localization of interictal epileptiform activity to the occipital lobes. Our hypothesis is that the siblings share a genetic focal epilepsy arising from a localized occipital network. Although they share many features of Gastaut syndrome, their refractory ongoing seizures in adolescence is unusual and likely due to underlying genetic determinants.
Gov't Doc #: 23294395
URI: http://ahro.austin.org.au/austinjspui/handle/1/11643
DOI: 10.1111/epi.12076
URL: https://pubmed.ncbi.nlm.nih.gov/23294395
Type: Journal Article
Subjects: Adolescent
Anticonvulsants.therapeutic use
Child
Data Interpretation, Statistical
Electroencephalography
Epilepsies, Partial.genetics.pathology.physiopathology
Epilepsy, Tonic-Clonic.genetics.pathology.physiopathology
Female
Humans
Intellectual Disability.pathology
Lennox Gastaut Syndrome
Magnetic Resonance Imaging
Male
Nerve Net.pathology.physiopathology
Neuroimaging
Occipital Lobe.pathology.physiopathology
Seizures.genetics.pathology.physiopathology
Siblings
Spasms, Infantile.pathology
Appears in Collections:Journal articles

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