Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11547
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dc.contributor.authorTsang, Benjamin K-T-
dc.contributor.authorCrump, Nicholas H-
dc.contributor.authorHughes, Andrew J-
dc.date.accessioned2015-05-16T01:09:40Z
dc.date.available2015-05-16T01:09:40Z
dc.date.issued2012-08-11-
dc.identifier.citationJournal of Clinical Neuroscience 2012; 19(10): 1459-61en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/11547en
dc.description.abstractWe present a 58-year-old female with gradual cognitive decline and gait instability over 6 months. Her motor examination was notable for myoclonus, brisk reflexes with flexor plantar responses, and a cautious gait without ataxia. Cognitive testing revealed mildly impaired attention, but profoundly impaired calculation, judgment and visual memory. There were no manifestations of autoimmune thyroid disease. Routine laboratory analysis was unrevealing. Cerebrospinal fluid analysis was remarkable only for an elevated protein of 0.64 g/L (normal <0.45 g/L). Electroencephalography demonstrated intermittent bitemporal slowing. Brain MRI with gadolinium demonstrated extensive bilateral subcortical and periventricular white matter T2-weighted and hyperintensity on fluid attenuated inversion recovery MRI. Elevated anti-thyroperoxidase antibody of 8.07 IU/mL (<5.61 IU/mL) and thyroglobin antibody of 9.85 IU/mL (<4.11 IU/mL) were found and steroid responsive encephalopathy associated with autoimmune thyroiditis was diagnosed. Methylprednisolone (1 g daily for 3 days) resulted in dramatic improvement in cognition and mobility, which remained on follow-up.en
dc.language.isoenen
dc.subject.otherAntibodies.blood.cerebrospinal fluiden
dc.subject.otherBrain Diseases.cerebrospinal fluid.drug therapy.etiologyen
dc.subject.otherCognition Disorders.cerebrospinal fluid.etiologyen
dc.subject.otherElectroencephalographyen
dc.subject.otherFemaleen
dc.subject.otherGlucocorticoids.therapeutic useen
dc.subject.otherHumansen
dc.subject.otherMagnetic Resonance Imagingen
dc.subject.otherMethylprednisolone.therapeutic useen
dc.subject.otherMiddle Ageden
dc.subject.otherPeroxidase.immunologyen
dc.subject.otherThyroglobulin.immunologyen
dc.subject.otherThyroiditis, Autoimmune.cerebrospinal fluid.complications.diagnosisen
dc.subject.otherTomography, X-Ray Computeden
dc.titleA patient with steroid responsive encephalopathy associated with autoimmune thyroiditis.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Clinical Neuroscienceen
dc.identifier.affiliationDepartment of Neurology, Austin Health, Studley Road, Heidelberg, Victoria 3084, Australiaen
dc.identifier.doi10.1016/j.jocn.2012.02.014en
dc.description.pages1459-61en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/22884222en
dc.type.contentTexten
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptNeurology-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptNeurology-
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