Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11544
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dc.contributor.authorKlein, Karl Martinen
dc.contributor.authorXu, San Sanen
dc.contributor.authorLawrence, Kate Men
dc.contributor.authorFischer, Alexandraen
dc.contributor.authorBerkovic, Samuel Fen
dc.date.accessioned2015-05-16T01:09:29Z
dc.date.available2015-05-16T01:09:29Z
dc.date.issued2012-08-07en
dc.identifier.citationNeurology; 79(6): 561-5en
dc.identifier.govdoc22869686en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/11544en
dc.description.abstractVasovagal syncope (VVS) is the most frequent type of syncope and a common differential diagnosis of epilepsy. The role of genetic factors in VVS is debated. We performed a twin-family study to clarify this question and to analyze the putative mode of inheritance.Fifty-one same-sex twin pairs where at least 1 had syncope were ascertained. The twins were interviewed via telephone using a standardized questionnaire. Available medical records were obtained. Information on the affected status of first- and second-degree relatives was acquired.There was a trend toward higher casewise concordance in monozygous (MZ, 0.75) than dizygous (DZ, 0.50) twins for any syncope (p = 0.06). Significant and strong effects on concordance between MZ and DZ twins were found for fainting at least twice unrelated to external circumstances (0.71 vs 0.27, p = 0.018) and for syncope associated with typical vasovagal triggers (0.62 vs 0.00, p < 0.001). Twelve of 19 concordant MZ twin pairs reported sparse or no other affected family members whereas in the other 7 pairs multiple close relatives were affected.The twin analysis provides strong evidence for the relevance of genetic factors in VVS. Analysis of the families suggests that complex inheritance (multiple genes ± environmental factors) is usual, with rarer families possibly segregating a major autosomal dominant gene.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherDiseases in Twins.geneticsen
dc.subject.otherFemaleen
dc.subject.otherGenetic Predisposition to Diseaseen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherSyncope, Vasovagal.geneticsen
dc.subject.otherTwins, Dizygotic.geneticsen
dc.subject.otherTwins, Monozygotic.geneticsen
dc.titleEvidence for genetic factors in vasovagal syncope: a twin-family study.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeurologyen
dc.identifier.affiliationEpilepsy Research Centre, The University of Melbourne, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1212/WNL.0b013e3182635789en
dc.description.pages561-5en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/22869686en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
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