Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11542
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dc.contributor.authorArora, Rajneet-
dc.contributor.authorHare, David L-
dc.contributor.authorZulli, Anthony-
dc.date.accessioned2015-05-16T01:09:21Z
dc.date.available2015-05-16T01:09:21Z
dc.date.issued2012-07-27en
dc.identifier.citationJournal of Atherosclerosis and Thrombosis 2012; 19(8): 705-11en
dc.identifier.govdoc22850448en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11542en
dc.description.abstractIn vivo evidence for the pleiotropic effects of simvastatin on the nitric oxide synthase system is limited.To determine if simvastatin can affect the endothelial nitric oxide synthase cascade.New Zealand white rabbits (n=15) were divided: Group 1 (control) was fed a normal rabbit diet; Group 2 (MC) received a normal rabbit diet with 1% methionine (M) plus 0.5% cholesterol (C) and 5% peanut oil (atherogenic diet); Group 3 received the same diet as the MC group plus 5 mg/kg/ day simvastatin (S) orally (MCS). After 4 weeks, the abdominal aorta was collected and analyzed.Total cholesterol (TC) and total homocysteine (tHcy) were not significantly different between MCS and MC. Endothelial function was only reduced in MC (p<0.05). Although eNOS significantly increased in MC and MCS (p<0.01), simvastatin treatment significantly reduced endothelial caveolin-1 by 35% (p=0.038), causing a 2.5-fold (p=0.026) increase in the eNOS: caveolin-1 ratio. The phosphorylation of eNOS at the threonine 495 site or serine 1177 site was not affected by diet or treatment; however, a positive correlation between the two phosphorylation sites was observed (r(2)= 0.5, p=0.01).in vivo pleiotropic effects of statin therapy include decreasing endothelial caveolin-1. Other therapies designed to affect eNOS phosphorylation in vivo might be useful in further preventing CVD.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherAorta, Abdominal.cytology.drug effects.metabolismen
dc.subject.otherCaveolin 1.metabolismen
dc.subject.otherCells, Cultureden
dc.subject.otherCholesterol.metabolismen
dc.subject.otherDiet, Atherogenicen
dc.subject.otherEndothelium, Vascular.cytology.drug effects.enzymologyen
dc.subject.otherHydroxymethylglutaryl-CoA Reductase Inhibitors.pharmacologyen
dc.subject.otherImmunoenzyme Techniquesen
dc.subject.otherMaleen
dc.subject.otherNitric Oxide Synthase Type III.metabolismen
dc.subject.otherRabbitsen
dc.subject.otherSimvastatin.pharmacologyen
dc.titleSimvastatin reduces endothelial NOS: caveolin-1 ratio but not the phosphorylation status of eNOS in vivo.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of atherosclerosis and thrombosisen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin Health, Australiaen
dc.description.pages705-11en
dc.identifier.orcid0000-0001-9554-6556-
dc.identifier.pubmedid22850448-
dc.type.austinJournal Articleen
local.name.researcherHare, David L
item.languageiso639-1en-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptCardiology-
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