Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11540
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dc.contributor.authorWiddop, Robert Een
dc.contributor.authorVerberne, Anthony J Men
dc.contributor.authorLouis, William Jen
dc.contributor.authorJarrott, Ben
dc.date.accessioned2015-05-16T01:09:14Z
dc.date.available2015-05-16T01:09:14Z
dc.date.issued1990-09-04en
dc.identifier.citationEuropean Journal of Pharmacology; 186(1): 17-28en
dc.identifier.govdoc2282935en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/11540en
dc.description.abstractThe effect of ketanserin (3 mg/kg i.v.) on the baroreceptor heart rate reflex and the Bezold-Jarisch reflex was examined in conscious Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). In the control situation (before ketanserin treatment), reflex bradycardia in response to phenylephrine (baroreflex) and phenyldiguanide (Bezold-Jarisch reflex) were impaired in SHR as compared with WKY, while reflex tachycardia in response to nitroprusside was similar in the two groups. However, after ketanserin administration in SHR, there was a reversal of the baroreflex-mediated tachycardia in response to nitroprusside into a bradycardic response. The nitroprusside-induced bradycardia was not caused by the release of 5-HT stimulating chemosensitive vagal afferents since the 5-HT3 receptor antagonist MDL 72222 did not block this response. In the same SHR, the Bezold-Jarisch reflex evoked by phenyldiguanide and the phenylephrine-induced bradycardia were potentiated by ketanserin. All the above effects of ketanserin were less evident in the WKY. Ketanserin did not alter vagal efferent function in anaesthetized SHR since it did not affect bradycardia induced by electrical stimulation of the vagus nerve. Therefore, it is suggested that ketanserin has sensitised cardiac vagal afferent mechanisms in SHR, which led to a normalization of reflex bradycardic function to a level normally observed in conscious normotensive WKY (i.e. prior to ketanserin treatment).en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherAtropine.pharmacologyen
dc.subject.otherBiguanides.pharmacologyen
dc.subject.otherBlood Pressure.drug effectsen
dc.subject.otherCardiovascular System.drug effectsen
dc.subject.otherDose-Response Relationship, Drugen
dc.subject.otherElectric Stimulationen
dc.subject.otherFemaleen
dc.subject.otherHeart Rate.drug effectsen
dc.subject.otherHypoglycemic Agents.pharmacologyen
dc.subject.otherKetanserin.pharmacologyen
dc.subject.otherNitroprusside.pharmacologyen
dc.subject.otherPressoreceptors.drug effectsen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred SHRen
dc.subject.otherRats, Inbred WKYen
dc.subject.otherReflex.drug effectsen
dc.subject.otherTropanes.pharmacologyen
dc.subject.otherVagus Nerve.physiologyen
dc.titleThe effect of ketanserin on cardiovascular reflexes in conscious normotensive and spontaneously hypertensive rats.en
dc.typeJournal Articleen
dc.identifier.journaltitleEuropean Journal of Pharmacologyen
dc.identifier.affiliationUniversity of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages17-28en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2282935en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
crisitem.author.deptClinical Pharmacology and Therapeutics-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptClinical Pharmacology and Therapeutics-
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