Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11504
Full metadata record
DC FieldValueLanguage
dc.contributor.authorChang, Joe H-
dc.contributor.authorLim Joon, Daryl-
dc.contributor.authorLee, Sze Ting-
dc.contributor.authorGong, Sylvia J-
dc.contributor.authorAnderson, Nigel J-
dc.contributor.authorScott, Andrew M-
dc.contributor.authorDavis, Ian D-
dc.contributor.authorClouston, David-
dc.contributor.authorBolton, Damien M-
dc.contributor.authorHamilton, Christopher S-
dc.contributor.authorKhoo, Vincent-
dc.date.accessioned2015-05-16T01:07:03Z
dc.date.available2015-05-16T01:07:03Z
dc.date.issued2012-05-30-
dc.identifier.citationInternational Journal of Radiation Oncology, Biology, Physics 2012; 83(5): e691-6en_US
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11504en
dc.description.abstractTo demonstrate the technical feasibility of intensity modulated radiation therapy (IMRT) dose painting using (11)C-choline positron emission tomography PET scans in patients with localized prostate cancer.This was an RT planning study of 8 patients with prostate cancer who had (11)C-choline PET scans prior to radical prostatectomy. Two contours were semiautomatically generated on the basis of the PET scans for each patient: 60% and 70% of the maximum standardized uptake values (SUV(60%) and SUV(70%)). Three IMRT plans were generated for each patient: PLAN(78), which consisted of whole-prostate radiation therapy to 78 Gy; PLAN(78-90), which consisted of whole-prostate RT to 78 Gy, a boost to the SUV(60%) to 84 Gy, and a further boost to the SUV(70%) to 90 Gy; and PLAN(72-90), which consisted of whole-prostate RT to 72 Gy, a boost to the SUV(60%) to 84 Gy, and a further boost to the SUV(70%) to 90 Gy. The feasibility of these plans was judged by their ability to reach prescription doses while adhering to published dose constraints. Tumor control probabilities based on PET scan-defined volumes (TCP(PET)) and on prostatectomy-defined volumes (TCP(path)), and rectal normal tissue complication probabilities (NTCP) were compared between the plans.All plans for all patients reached prescription doses while adhering to dose constraints. TCP(PET) values for PLAN(78), PLAN(78-90), and PLAN(72-90) were 65%, 97%, and 96%, respectively. TCP(path) values were 71%, 97%, and 89%, respectively. Both PLAN(78-90) and PLAN(72-90) had significantly higher TCP(PET) (P=.002 and .001) and TCP(path) (P<.001 and .014) values than PLAN(78). PLAN(78-90) and PLAN(72-90) were not significantly different in terms of TCP(PET) or TCP(path). There were no significant differences in rectal NTCPs between the 3 plans.IMRT dose painting for localized prostate cancer using (11)C-choline PET scans is technically feasible. Dose painting results in higher TCPs without higher NTCPs.en_US
dc.language.isoenen
dc.subject.otherAgeden
dc.subject.otherCarbon Radioisotopes.diagnostic useen
dc.subject.otherCholine.diagnostic useen
dc.subject.otherFeasibility Studiesen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherModels, Biologicalen
dc.subject.otherOrgans at Risken
dc.subject.otherPositron-Emission Tomography.methodsen
dc.subject.otherProstate.pathology.radionuclide imagingen
dc.subject.otherProstatectomyen
dc.subject.otherProstatic Neoplasms.pathology.radionuclide imaging.radiotherapy.surgeryen
dc.subject.otherRadiotherapy Dosageen
dc.subject.otherRadiotherapy Planning, Computer-Assisted.methodsen
dc.subject.otherRadiotherapy, Intensity-Modulated.methodsen
dc.subject.otherRectumen
dc.subject.otherTumor Burdenen
dc.titleIntensity modulated radiation therapy dose painting for localized prostate cancer using ¹¹C-choline positron emission tomography scans.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleInternational Journal of Radiation Oncology, Biology, Physicsen_US
dc.identifier.affiliationRadiation Oncologyen_US
dc.identifier.doi10.1016/j.ijrobp.2012.01.087en_US
dc.description.pagese691-6en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/22658218en
dc.type.contentTexten_US
dc.type.austinJournal Articleen
local.name.researcherBolton, Damien M
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptRadiation Oncology-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
crisitem.author.deptUrology-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

40
checked on Dec 26, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.