Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11488
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dc.contributor.authorMorimatsu, Hiroshien
dc.contributor.authorIshikawa, Kenen
dc.contributor.authorMay, Clive Nen
dc.contributor.authorBailey, Michael Jen
dc.contributor.authorBellomo, Rinaldoen
dc.date.accessioned2015-05-16T01:06:03Z
dc.date.available2015-05-16T01:06:03Z
dc.date.issued2012-05-14en
dc.identifier.citationAnesthesia and Analgesia 2012; 115(2): 330-42en
dc.identifier.govdoc22584559en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11488en
dc.description.abstractPhenylephrine treatment of hypotension in sepsis raises concern because it may decrease vital organ bloodflow. Accordingly, we investigated the effects of phenylephrine on systemic and regional bloodflow in normal and septic sheep.Responses to phenylephrine or vehicle infusion for 6 hours were determined in conscious normal sheep and sheep with early sepsis induced by administration of live Escherichia coli. Cardiac output and coronary, mesenteric, and renal bloodflow were measured with implanted flow probes.In normal sheep, phenylephrine decreased cardiac output and heart rate (HR) but increased stroke volume and mean arterial blood pressure (MAP) (84 ± 6 to 108 ± 6 mm Hg, magnitude of mean difference [diff.] 19 [22.6%]; 95% confidence intervals [CI], 17-21). There were significant decreases in regional conductance values with a transient decrease in mesenteric bloodflow, no change in coronary bloodflow, and increased renal bloodflow (222 ± 53 to 271 ± 55 mL/min; diff. 31 [13.9%]; 95% CI, 26-36). During hyperdynamic sepsis, vasodilatation and increased bloodflow occurred in all vascular beds. Phenylephrine restored MAP and stroke volume to baseline values, but HR, cardiac output, and total peripheral conductance progressively decreased. Phenylephrine decreased mesenteric and coronary conductance, with no sustained reduction in flows, but renal conductance was significantly decreased and overall renal bloodflow increased (293 ± 22 vs 347 ± 100 mL/min; diff. 55 [18.8%]; 95% CI, 47-65).In sheep with early hyperdynamic sepsis, phenylephrine, at a dose that restored MAP, increased stroke volume and renal bloodflow while decreasing HR and coronary bloodflow but not mesenteric bloodflow. Similar responses were seen in normal animals.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherCardiac Output.drug effectsen
dc.subject.otherCoronary Circulation.drug effectsen
dc.subject.otherDisease Models, Animalen
dc.subject.otherEscherichia colien
dc.subject.otherFemaleen
dc.subject.otherHeart Rate.drug effectsen
dc.subject.otherHemodynamics.drug effectsen
dc.subject.otherHypotension.drug therapy.microbiology.physiopathologyen
dc.subject.otherInfusions, Intravenousen
dc.subject.otherPhenylephrine.administration & dosage.pharmacologyen
dc.subject.otherRegional Blood Flow.drug effectsen
dc.subject.otherRenal Circulation.drug effectsen
dc.subject.otherSepsis.drug therapy.microbiology.physiopathologyen
dc.subject.otherSheepen
dc.subject.otherSplanchnic Circulation.drug effectsen
dc.subject.otherTime Factorsen
dc.subject.otherVasoconstrictor Agents.administration & dosage.pharmacologyen
dc.subject.otherVasodilation.drug effectsen
dc.titleThe systemic and regional hemodynamic effects of phenylephrine in sheep under normal conditions and during early hyperdynamic sepsis.en
dc.typeJournal Articleen
dc.identifier.journaltitleAnesthesia and analgesiaen
dc.identifier.affiliationDepartment of Intensive Care, Austin Health, Heidelberg, Victoria, Australia, Heidelberg, Victoria 3084, Australiaen
dc.identifier.doi10.1213/ANE.0b013e31825681aben
dc.description.pages330-42en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/22584559en
dc.type.austinJournal Articleen
local.name.researcherBellomo, Rinaldo
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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