Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11483
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dc.contributor.authorGrace, Josephine A-
dc.contributor.authorHerath, Chandana B-
dc.contributor.authorMak, Kai Yan-
dc.contributor.authorBurrell, Louise M-
dc.contributor.authorAngus, Peter W-
dc.date.accessioned2015-05-16T01:05:44Z
dc.date.available2015-05-16T01:05:44Z
dc.date.issued2012-08-01-
dc.identifier.citationClinical Science 2012; 123(4): 225-39en_US
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11483en
dc.description.abstractThe RAS (renin-angiotensin system) is now recognized as an important regulator of liver fibrosis and portal pressure. Liver injury stimulates the hepatic expression of components of the RAS, such as ACE (angiotensin-converting enzyme) and the AT(1) receptor [AngII (angiotensin II) type 1 receptor], which play an active role in promoting inflammation and deposition of extracellular matrix. In addition, the more recently recognized structural homologue of ACE, ACE2, is also up-regulated. ACE2 catalyses the conversion of AngII into Ang-(1-7) [angiotensin-(1-7)], and there is accumulating evidence that this 'alternative axis' of the RAS has anti-fibrotic, vasodilatory and anti-proliferative effects, thus counterbalancing the effects of AngII in the liver. The RAS is also emerging as an important contributor to the pathophysiology of portal hypertension in cirrhosis. Although the intrahepatic circulation in cirrhosis is hypercontractile in response to AngII, resulting in increased hepatic resistance, the splanchnic vasculature is hyporesponsive, promoting the development of the hyperdynamic circulation that characterizes portal hypertension. Both liver fibrosis and portal hypertension represent important therapeutic challenges for the clinician, and there is accumulating evidence that RAS blockade may be beneficial in these circumstances. The present review outlines new aspects of the RAS and explores its role in the pathogenesis and treatment of liver fibrosis and portal hypertension.en_US
dc.language.isoenen
dc.subject.otherAngiotensin II.geneticsen
dc.subject.otherAngiotensin II Type 1 Receptor Blockers.therapeutic useen
dc.subject.otherAngiotensin-Converting Enzyme Inhibitors.therapeutic useen
dc.subject.otherAnimalsen
dc.subject.otherHepatorenal Syndrome.physiopathologyen
dc.subject.otherHumansen
dc.subject.otherHypertension, Portal.drug therapy.physiopathologyen
dc.subject.otherLiver.drug effectsen
dc.subject.otherLiver Cirrhosis.drug therapy.physiopathologyen
dc.subject.otherPeptidyl-Dipeptidase A.metabolismen
dc.subject.otherRenin-Angiotensin System.drug effects.physiologyen
dc.subject.otherSplanchnic Circulation.drug effectsen
dc.subject.otherVasodilation.drug effectsen
dc.titleUpdate on new aspects of the renin-angiotensin system in liver disease: clinical implications and new therapeutic options.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleClinical Scienceen_US
dc.identifier.affiliationMedicine (University of Melbourne)en_US
dc.identifier.doi10.1042/CS20120030en_US
dc.description.pages225-39en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/22548407en
dc.type.contentTexten_US
dc.type.austinJournal Articleen
local.name.researcherAngus, Peter W
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptCardiology-
crisitem.author.deptGeneral Medicine-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
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