Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11464
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dc.contributor.authorSatasivam, Prassannahen
dc.contributor.authorSengupta, Shomiken
dc.contributor.authorRajarubendra, Nieroshanen
dc.contributor.authorChia, Ping Hanen
dc.contributor.authorMunshey, Aasheenen
dc.contributor.authorBolton, Damien Men
dc.date.accessioned2015-05-16T01:04:32Z
dc.date.available2015-05-16T01:04:32Z
dc.date.issued2012-04-01en
dc.identifier.citationBJU International; 109 Suppl 3(): 44-7en
dc.identifier.govdoc22458493en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11464en
dc.description.abstractTo validate the relationship of the R.E.N.A.L nephrometry score to histological features of renal lesions treated by surgical excision by radical nephrectomy (RN) or nephron-sparing surgery (NSS) at an Australian tertiary referral centre.Patients undergoing surgery between 2005 and 2009 with imaging studies available were included. The R.E.N.A.L. nephrometry score is an objective measure of factors important in determining suitability for NSS, e.g. size, exophytic nature, proximity to collecting system and polar location, and R.E.N.A.L scoring was done using the online template at http://www.nephrometry.com. Pathological details were collected by retrospective chart review. Comparisons were made using chi-squared or Fisher's exact tests and trends analysed by linear regression.The rate of benign pathology decreased from 12/58 (20.7%) low-complexity lesions to 1/16 (6.2%) high-complexity lesions (P= 0.09), renal cell carcinomas (RCCs) were stable between 45/58 (77.6%) and 13/16 (81.2%), but other malignancies increased (P= 0.058) from 1/58 (1.7%) to 2/16 (12.5%). Among the RCCs, high vs low R.E.N.A.L score was associated with an increasing risk of clear cell histology (84.6% vs 64.4%, P < 0.05), stage ≥ pT3 (76.9% vs 8.9%, P < 0.001) and grade 4 tumours (15.4% vs 2.2%, P < 0.05), and conversely with a lower risk of papillary histology (0% vs 24.4%, P < 0.02) and stage T1a (0% vs 84.4%, P < 0.001).Increasing R.E.N.A.L score is associated with histological features of tumour aggressiveness, thus reinforcing the need for RN for lesions with a high score, and conversely the safety of NSS or observation for lesions with a low score.en
dc.language.isoenen
dc.subject.otherBiopsyen
dc.subject.otherCarcinoma, Renal Cell.epidemiology.pathology.surgeryen
dc.subject.otherCross-Sectional Studiesen
dc.subject.otherDiagnosis, Differentialen
dc.subject.otherDisease Progressionen
dc.subject.otherHumansen
dc.subject.otherIncidenceen
dc.subject.otherKidney.pathology.surgeryen
dc.subject.otherKidney Neoplasms.epidemiology.pathology.surgeryen
dc.subject.otherNeoplasm Staging.methodsen
dc.subject.otherNephrectomyen
dc.subject.otherPrognosisen
dc.subject.otherRetrospective Studiesen
dc.subject.otherSurvival Rate.trendsen
dc.subject.otherVictoria.epidemiologyen
dc.titleRenal lesions with low R.E.N.A.L nephrometry score are associated with more indolent renal cell carcinomas (RCCs) or benign histology: findings in an Australian cohort.en
dc.typeJournal Articleen
dc.identifier.journaltitleBJU Internationalen
dc.identifier.affiliationDepartment of Urology, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1111/j.1464-410X.2012.11046.xen
dc.description.pages44-7en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/22458493en
dc.type.austinJournal Articleen
local.name.researcherBolton, Damien M
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptUrology-
crisitem.author.deptUrology-
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