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Title: Antibody therapy of cancer.
Austin Authors: Scott, Andrew M ;Wolchok, Jedd D;Old, Lloyd J
Affiliation: Ludwig Institute for Cancer Research; University of Melbourne; and Centre for PET, Austin Hospital, Melbourne, Victoria 3084, Australia
Issue Date: 22-Mar-2012
Publication information: Nature Reviews. Cancer 2012; 12(4): 278-87
Abstract: The use of monoclonal antibodies (mAbs) for cancer therapy has achieved considerable success in recent years. Antibody-drug conjugates are powerful new treatment options for lymphomas and solid tumours, and immunomodulatory antibodies have also recently achieved remarkable clinical success. The development of therapeutic antibodies requires a deep understanding of cancer serology, protein-engineering techniques, mechanisms of action and resistance, and the interplay between the immune system and cancer cells. This Review outlines the fundamental strategies that are required to develop antibody therapies for cancer patients through iterative approaches to target and antibody selection, extending from preclinical studies to human trials.
Gov't Doc #: 22437872
DOI: 10.1038/nrc3236
Journal: Nature reviews. Cancer
Type: Journal Article
Subjects: Animals
Antibodies, Monoclonal.pharmacokinetics.pharmacology.therapeutic use
Antigens, Neoplasm.immunology.metabolism
Antineoplastic Agents.pharmacokinetics.pharmacology.therapeutic use
Clinical Trials as Topic
Drug Approval
Drug Carriers.therapeutic use
Drug Resistance, Neoplasm
Neoplasms.drug therapy.metabolism
Tissue Distribution
Tumor Escape
Appears in Collections:Journal articles

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