Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11423
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dc.contributor.authorEbert, Lisa Men
dc.contributor.authorMacRaild, Sarah Een
dc.contributor.authorDavis, Ian Den
dc.contributor.authorCebon, Jonathan Sen
dc.contributor.authorChen, Weisanen
dc.date.accessioned2015-05-16T01:01:46Z
dc.date.available2015-05-16T01:01:46Z
dc.date.issued2012-01-13en
dc.identifier.citationJournal of Immunological Methods 2012; 377(1-2): 56-61en
dc.identifier.govdoc22265970en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11423en
dc.description.abstractAntigenic epitopes recognized by FoxP3(+) regulatory T cells (Treg) are poorly defined, largely due to a lack of assays for determining Treg specificity. We have developed a novel approach for detecting human Treg specific to peptide antigen, utilizing down-regulation of surface CD3 as a read-out of antigen recognition. Culture conditions and re-stimulation time have been optimized, allowing the detection of even very rare Treg, such as those specific to tumor antigens.en
dc.language.isoenen
dc.subject.otherAntigen Presentation.immunologyen
dc.subject.otherAntigens, CD3.genetics.immunologyen
dc.subject.otherDown-Regulation.immunologyen
dc.subject.otherEpitopes, T-Lymphocyte.immunologyen
dc.subject.otherFlow Cytometry.methodsen
dc.subject.otherForkhead Transcription Factors.immunologyen
dc.subject.otherHumansen
dc.subject.otherT-Lymphocytes, Regulatory.immunologyen
dc.titleA novel method for detecting antigen-specific human regulatory T cells.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of immunological methodsen
dc.identifier.affiliationLudwig Institute for Cancer Research (Melbourne-Austin Branch), Melbourne, Australiaen
dc.identifier.doi10.1016/j.jim.2012.01.004en
dc.description.pages56-61en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/22265970en
dc.type.austinJournal Articleen
local.name.researcherCebon, Jonathan S
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
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