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DC Field | Value | Language |
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dc.contributor.author | Iuliano-Burns, Sandra | en |
dc.contributor.author | Ayton, J | en |
dc.contributor.author | Hillam, S | en |
dc.contributor.author | Jones, G | en |
dc.contributor.author | King, K | en |
dc.contributor.author | Macleod, S | en |
dc.contributor.author | Seeman, Ego | en |
dc.date.accessioned | 2015-05-16T01:00:13Z | - |
dc.date.available | 2015-05-16T01:00:13Z | - |
dc.date.issued | 2012-01-04 | en |
dc.identifier.citation | Osteoporosis International : A Journal Established As Result of Cooperation Between the European Foundation For Osteoporosis and the National Osteoporosis Foundation of The Usa 2012; 23(10): 2461-7 | en |
dc.identifier.govdoc | 22215183 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/11410 | en |
dc.description.abstract | Sunlight deprivation results in vitamin D deficiency but serum vitamin D levels can be maintained above 50 nmol/L when supplemented with 50,000 IU at least every alternate month.Antarctic expeditioners are exposed to prolonged sunlight deprivation resulting in vitamin D deficiency. We hypothesised that monthly dosing of 50,000 IU vitamin D (~1,600 IU daily) will increase serum 25-hydroxyvitamin D (25(OH)D), suppress parathyroid hormone (PTH) and improve bone mineral density (BMD), 50,000 IU alternate months (~800 IU daily) will maintain these measures, while a single 50,000 IU dose pre-departure (~1,00 IU daily) will not be protective.This was a randomised double-blind study involving 110 healthy adults: 91 males, mean age 41 years (range 24-65 years) working in Antarctica for up to 12 months, who we administered 50,000 IU vitamin D3 monthly, alternate months or a single dose pre-departure. Serum 25(OH)D, PTH, osteocalcin, CTx and calcium were assessed at baseline, mid- and end of expedition. Proximal femur and lumbar spine BMD were assessed pre- and post-expedition.Baseline 25(OH)D was 59 ± 14 nmol/L. By mid-expedition, 25(OH)D increased by 7 nmol/L in those supplemented monthly (p < 0.05) and remained unchanged in those supplemented in alternate months. In those given a single dose pre-departure, 25(OH)D decreased by 8 nmol/L (p < 0.05) and PTH increased by 27% (p < 0.09). Serum osteocalcin increased by ~22% in all groups but BMD remained unchanged. If serum 25(OH)D was >50 nmol/L at baseline, 25(OH)D was maintained above this level with all regimens. If 25(OH)D was <50 nmol/L at baseline, monthly or alternate month regimens were needed to achieve levels >50 nmol/L, the single pre-departure dose was ineffective.During sunlight deprivation of up to 12 months, serum 25(OH)D levels can be maintained above 50 nmol/L when expeditioners are provided with 50,000 I U at least every alternate month. | en |
dc.language.iso | en | en |
dc.subject.other | Adult | en |
dc.subject.other | Aged | en |
dc.subject.other | Antarctic Regions | en |
dc.subject.other | Calcium.blood | en |
dc.subject.other | Dietary Supplements | en |
dc.subject.other | Double-Blind Method | en |
dc.subject.other | Drug Administration Schedule | en |
dc.subject.other | Expeditions | en |
dc.subject.other | Female | en |
dc.subject.other | Femur.physiopathology | en |
dc.subject.other | Humans | en |
dc.subject.other | Lumbar Vertebrae.physiopathology | en |
dc.subject.other | Male | en |
dc.subject.other | Middle Aged | en |
dc.subject.other | Osteocalcin.blood | en |
dc.subject.other | Parathyroid Hormone.blood | en |
dc.subject.other | Sunlight | en |
dc.subject.other | Vitamin D.administration & dosage.analogs & derivatives.blood.therapeutic use | en |
dc.subject.other | Vitamin D Deficiency.complications.physiopathology.prevention & control | en |
dc.subject.other | Young Adult | en |
dc.title | Skeletal and hormonal responses to vitamin D supplementation during sunlight deprivation in Antarctic expeditioners. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Osteoporosis International | en |
dc.identifier.affiliation | Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia | en |
dc.identifier.doi | 10.1007/s00198-011-1858-9 | en |
dc.description.pages | 2461-2467 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/22215183 | en |
dc.type.austin | Journal Article | en |
local.name.researcher | Iuliano-Burns, Sandra | |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | Journal Article | - |
item.fulltext | With Fulltext | - |
crisitem.author.dept | Medicine (University of Melbourne) | - |
crisitem.author.dept | Endocrinology | - |
crisitem.author.dept | Endocrinology | - |
Appears in Collections: | Journal articles |
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22215183.pdf | 54.43 kB | Adobe PDF | View/Open |
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