Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11410
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dc.contributor.authorIuliano-Burns, Sandraen
dc.contributor.authorAyton, Jen
dc.contributor.authorHillam, Sen
dc.contributor.authorJones, Gen
dc.contributor.authorKing, Ken
dc.contributor.authorMacleod, Sen
dc.contributor.authorSeeman, Egoen
dc.date.accessioned2015-05-16T01:00:13Z-
dc.date.available2015-05-16T01:00:13Z-
dc.date.issued2012-01-04en
dc.identifier.citationOsteoporosis International : A Journal Established As Result of Cooperation Between the European Foundation For Osteoporosis and the National Osteoporosis Foundation of The Usa 2012; 23(10): 2461-7en
dc.identifier.govdoc22215183en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11410en
dc.description.abstractSunlight deprivation results in vitamin D deficiency but serum vitamin D levels can be maintained above 50 nmol/L when supplemented with 50,000 IU at least every alternate month.Antarctic expeditioners are exposed to prolonged sunlight deprivation resulting in vitamin D deficiency. We hypothesised that monthly dosing of 50,000 IU vitamin D (~1,600 IU daily) will increase serum 25-hydroxyvitamin D (25(OH)D), suppress parathyroid hormone (PTH) and improve bone mineral density (BMD), 50,000 IU alternate months (~800 IU daily) will maintain these measures, while a single 50,000 IU dose pre-departure (~1,00 IU daily) will not be protective.This was a randomised double-blind study involving 110 healthy adults: 91 males, mean age 41 years (range 24-65 years) working in Antarctica for up to 12 months, who we administered 50,000 IU vitamin D3 monthly, alternate months or a single dose pre-departure. Serum 25(OH)D, PTH, osteocalcin, CTx and calcium were assessed at baseline, mid- and end of expedition. Proximal femur and lumbar spine BMD were assessed pre- and post-expedition.Baseline 25(OH)D was 59 ± 14 nmol/L. By mid-expedition, 25(OH)D increased by 7 nmol/L in those supplemented monthly (p < 0.05) and remained unchanged in those supplemented in alternate months. In those given a single dose pre-departure, 25(OH)D decreased by 8 nmol/L (p < 0.05) and PTH increased by 27% (p < 0.09). Serum osteocalcin increased by ~22% in all groups but BMD remained unchanged. If serum 25(OH)D was >50 nmol/L at baseline, 25(OH)D was maintained above this level with all regimens. If 25(OH)D was <50 nmol/L at baseline, monthly or alternate month regimens were needed to achieve levels >50 nmol/L, the single pre-departure dose was ineffective.During sunlight deprivation of up to 12 months, serum 25(OH)D levels can be maintained above 50 nmol/L when expeditioners are provided with 50,000 I U at least every alternate month.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAgeden
dc.subject.otherAntarctic Regionsen
dc.subject.otherCalcium.blooden
dc.subject.otherDietary Supplementsen
dc.subject.otherDouble-Blind Methoden
dc.subject.otherDrug Administration Scheduleen
dc.subject.otherExpeditionsen
dc.subject.otherFemaleen
dc.subject.otherFemur.physiopathologyen
dc.subject.otherHumansen
dc.subject.otherLumbar Vertebrae.physiopathologyen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherOsteocalcin.blooden
dc.subject.otherParathyroid Hormone.blooden
dc.subject.otherSunlighten
dc.subject.otherVitamin D.administration & dosage.analogs & derivatives.blood.therapeutic useen
dc.subject.otherVitamin D Deficiency.complications.physiopathology.prevention & controlen
dc.subject.otherYoung Adulten
dc.titleSkeletal and hormonal responses to vitamin D supplementation during sunlight deprivation in Antarctic expeditioners.en
dc.typeJournal Articleen
dc.identifier.journaltitleOsteoporosis Internationalen
dc.identifier.affiliationAustin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1007/s00198-011-1858-9en
dc.description.pages2461-2467en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/22215183en
dc.type.austinJournal Articleen
local.name.researcherIuliano-Burns, Sandra
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.openairetypeJournal Article-
item.fulltextWith Fulltext-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptEndocrinology-
crisitem.author.deptEndocrinology-
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