Decreased body weight in young Osterix-Cre transgenic mice results in delayed cortical bone expansion and accrual.

2011-12-13

Davey, Rachel A

Clarke, Michele V

Sastra, Stephen

Skinner, Jarrod P

Chiang, Cherie Ying

Anderson, Paul H

Zajac, Jeffrey D

Journal Article

10.1007/s11248-011-9581-z

Conditional gene inactivation using the Cre/loxP system has lead to significant advances in our understanding of the function of genes in a wide range of disciplines. It is becoming increasingly apparent in the literature, that Cre transgenic mice may themselves have a phenotype. In the following study we describe the bone phenotype of a commonly used Cre transgenic mouse line to study osteoblasts, the Osx-GFP

link

Transgenic Research 2011; 21(4): 885-93

Transgenic research