Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11395
Full metadata record
DC FieldValueLanguage
dc.contributor.authorChua, Horng-Rueyen
dc.contributor.authorGlassford, Neil Jen
dc.contributor.authorBellomo, Rinaldoen
dc.date.accessioned2015-05-16T00:59:09Z
dc.date.available2015-05-16T00:59:09Z
dc.date.issued2011-12-08en
dc.identifier.citationResuscitation 2011; 83(6): 721-7en
dc.identifier.govdoc22155699en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11395en
dc.description.abstractCardiac arrest (CA) in humans causes warm renal ischemia-reperfusion injury, similar to animal models of ischemic acute kidney injury (AKI). We aimed to investigate the incidence and risk associations of AKI after CA, with or without post-resuscitation cardiogenic shock (PRCS).We examined the renal outcomes of adult patients admitted to the intensive care unit (ICU), who survived for more than 48 h following successful resuscitation after CA.Of 105 patients (median age 65 years; 69% male), 58 (55.2%) had PRCS and were on vasoactive drugs beyond 24h; and 9 (8.6%) (all of whom had PRCS) received renal replacement therapy. Only 3 (6.4%) of 47 patients without PRCS had RIFLE-'I'/'F' AKI, compared to 30 (51.7%) of 58 patients with PRCS (p<0.001). Median peak serum creatinine in the non-PRCS group was 102 μmol/L (interquartile range 85-115), compared to 155 μmol/L (interquartile range 112-267) (p<0.001) in the PRCS group. On multivariate analysis, cumulative noradrenaline dose during the first 24h in ICU, PRCS, and pre-CA renin-angiotensin-aldosterone-system blockade were independently associated with RIFLE-'I'/'F' AKI; while higher serum lactate 12h after CA, baseline creatinine, and PRCS were independently associated with greater rise in creatinine from pre-CA levels. Estimated time without spontaneous circulation, total adrenaline dose and initial cardiac rhythm during CA, had no independent associations with renal outcomes.In the absence of PRCS, CA in isolation is uncommonly associated with significant AKI. The human kidney may be more resistant to warm ischemia-reperfusion injury than previously thought.en
dc.language.isoenen
dc.subject.otherAcute Kidney Injury.diagnosis.etiologyen
dc.subject.otherAgeden
dc.subject.otherBlood Circulationen
dc.subject.otherCardiopulmonary Resuscitationen
dc.subject.otherCreatinine.blooden
dc.subject.otherFemaleen
dc.subject.otherHeart Arrest.complications.physiopathology.therapyen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherReperfusion Injury.etiologyen
dc.subject.otherShock, Cardiogenic.etiologyen
dc.titleAcute kidney injury after cardiac arrest.en
dc.typeJournal Articleen
dc.identifier.journaltitleResuscitationen
dc.identifier.affiliationDepartment of Intensive Care, Austin Hospital, Melbourne, Australiaen
dc.identifier.doi10.1016/j.resuscitation.2011.11.030en
dc.description.pages721-7en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/22155699en
dc.type.austinJournal Articleen
local.name.researcherBellomo, Rinaldo
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

10
checked on Mar 29, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.