Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11272
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dc.contributor.authorFabris, Bruno-
dc.contributor.authorJackson, B-
dc.contributor.authorKohzuki, M-
dc.contributor.authorPerich, R-
dc.contributor.authorJohnston, Colin I-
dc.date.accessioned2015-05-16T00:51:40Z
dc.date.available2015-05-16T00:51:40Z
dc.date.issued1990-04-01-
dc.identifier.citationClinical and Experimental Pharmacology & Physiology; 17(4): 309-14en_US
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11272en
dc.description.abstract1. Chronic heart failure was induced in rats by ligation of the left coronary artery to produce a left ventricular myocardial infarct. 2. Cardiac angiotensin-converting enzyme (ACE) was estimated by radioligand binding in myocardial homogenates and by autoradiography studies of radioligand binding to ACE in heart sections. 3. Radioligand binding studies demonstrated an increase in binding sites in animals with myocardial infarction, compared with sham operated animals. Mean increases were 457% in right atrium, 295% in left atrium, 326% in right ventricle, 187% in left ventricle and 530% in the region of the left ventricular infarct, compared with the sham left ventricle. 4. Autoradiography studies confirmed tissue homogenate binding studies, demonstrating (i) a marked increase in ligand binding in the infarct area and (ii) an increase in binding density in the hypertrophied myocardium of right and left atrium, and right and left ventricle. 5. The induction of cardiac ACE in the myocardium of rats with chronic heart failure may participate in the pathophysiology of cardiac hypertrophy.en_US
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherAutoradiographyen
dc.subject.otherCardiac Output, Low.complications.enzymologyen
dc.subject.otherFemaleen
dc.subject.otherMyocardial Infarction.complications.enzymologyen
dc.subject.otherMyocardium.enzymologyen
dc.subject.otherPeptidyl-Dipeptidase A.metabolismen
dc.subject.otherProtein Bindingen
dc.subject.otherRadioligand Assayen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred Strainsen
dc.titleIncreased cardiac angiotensin-converting enzyme in rats with chronic heart failure.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleClinical and Experimental Pharmacology & Physiologyen_US
dc.identifier.affiliationMedicine (University of Melbourne)en_US
dc.description.pages309-14en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2161305en
dc.type.contentTexten_US
dc.type.austinJournal Articleen
local.name.researcherJackson, Belinda D
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptGastroenterology and Hepatology-
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