Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11245
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dc.contributor.authorProwle, John Ren
dc.contributor.authorSchneider, Antoine Gen
dc.contributor.authorBellomo, Rinaldoen
dc.date.accessioned2015-05-16T00:50:02Z
dc.date.available2015-05-16T00:50:02Z
dc.date.issued2011-03-18en
dc.identifier.citationCritical Care 2011; 15(2): 207en
dc.identifier.govdoc21489322en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11245en
dc.description.abstractContinuous renal replacement therapy (CRRT) is the preferred treatment for acute kidney injury in intensive care units (ICUs) throughout much of the world. Despite the widespread use of CRRT, controversy and center-specific practice variation in the clinical application of CRRT continue. In particular, whereas two single-center studies have suggested survival benefit from delivery of higher-intensity CRRT to patients with acute kidney injury in the ICU, other studies have been inconsistent in their results. Now, however, two large multi-center randomized controlled trials - the Veterans Affairs/National Institutes of Health Acute Renal Failure Trial Network (ATN) study and the Randomized Evaluation of Normal versus Augmented Level (RENAL) Replacement Therapy Study - have provided level 1 evidence that effluent flow rates above 25 mL/kg per hour do not improve outcomes in patients in the ICU. In this review, we discuss the concept of dose of CRRT, its relationship with clinical outcomes, and what target optimal dose of CRRT should be pursued in light of the high-quality evidence now available.en
dc.language.isoenen
dc.subject.otherAcute Kidney Injury.therapyen
dc.subject.otherDose-Response Relationship, Drugen
dc.subject.otherEvidence-Based Medicineen
dc.subject.otherHumansen
dc.subject.otherIntensive Care.methodsen
dc.subject.otherRandomized Controlled Trials as Topicen
dc.subject.otherRenal Replacement Therapy.methodsen
dc.subject.otherTreatment Outcomeen
dc.titleClinical review: Optimal dose of continuous renal replacement therapy in acute kidney injury.en
dc.typeJournal Articleen
dc.identifier.journaltitleCritical Careen
dc.identifier.affiliationDepartment of Intensive Care, Austin Health, 145 Studley Road, Heidelberg, Victoria 3084, Australiaen
dc.identifier.doi10.1186/cc9415en
dc.description.pages207en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/21489322en
dc.type.austinJournal Articleen
local.name.researcherBellomo, Rinaldo
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
Appears in Collections:Journal articles
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