Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11218
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dc.contributor.authorZebaze, Roger M Den
dc.contributor.authorJones, Anthony Cen
dc.contributor.authorPandy, Marcus Gen
dc.contributor.authorKnackstedt, Mark Aen
dc.contributor.authorSeeman, Egoen
dc.date.accessioned2015-05-16T00:48:24Z
dc.date.available2015-05-16T00:48:24Z
dc.date.issued2011-03-06en
dc.identifier.citationBone 2011; 48(6): 1246-51en
dc.identifier.govdoc21385633en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/11218en
dc.description.abstractStudy of postmortem samples of cortical bone from the trochanters of 12 Caucasian females revealed that tissue mineral density (TMD) and tissue elastic modulus correlate weakly within and between individuals. Other material properties need to be taken into account to more fully predict variation in tissue elastic modulus.Bone is a composite material that varies in its material composition and structural organization at the macro-, micro-, and nano-scales. This hierarchical organization is essential for bone's resistance to crack initiation and propagation. We quantified the relationship between regional heterogeneity in TMD and tissue elastic modulus in cortical bone of the trochanter to determine whether TMD can be used as a predictor of tissue elastic modulus.Measurements of tissue elastic modulus and hardness were made using nanoindentation at 5 × 20 indent points spaced 100 μm apart. TMD at the same location was computed from quantitative backscattered scanning electron microscopy imaging of cortical samples from trochanters obtained at postmortem from 12 Caucasian females (mean age: 69 years; range: 29 to 85 years).Within an individual, the variance in tissue elastic modulus (CV = 18.7%; range: 9 to 41.5%) was five times greater than the variance in TMD (3.6%, range: 1.8 to 5.7%). On average, only 45% of the variance in tissue elastic modulus was explained by TMD. From individual to individual, the proportion of the variance in tissue elastic modulus explained by TMD ranged from 0 to 64%. In 6 of 12 samples, TMD explained less than 30% of the variance in tissue elastic modulus. Results were similar for tissue hardness.Tissue mineral density is an incomplete surrogate for tissue elastic modulus. Other material properties need to be accounted for to more fully predict regional variation in tissue elastic modulus.en
dc.language.isoenen
dc.subject.otherBone and Bones.physiology.ultrastructureen
dc.subject.otherCalcification, Physiologicen
dc.subject.otherElasticityen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMicroscopy, Electron, Scanningen
dc.titleDifferences in the degree of bone tissue mineralization account for little of the differences in tissue elastic properties.en
dc.typeJournal Articleen
dc.identifier.journaltitleBoneen
dc.identifier.affiliationDepartments of Endocrinology & Medicine, Austin Health, University of Melbourne, Melbourne, Australiaen
dc.identifier.doi10.1016/j.bone.2011.02.023en
dc.description.pages1246-51en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/21385633en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
crisitem.author.deptEndocrinology-
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