Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11175
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLim, E J-
dc.contributor.authorCrowley, Peter-
dc.contributor.authorMitchell, C A-
dc.contributor.authorAngus, Peter W-
dc.date.accessioned2015-05-16T00:45:47Z
dc.date.available2015-05-16T00:45:47Z
dc.date.issued2011-01-01-
dc.identifier.citationAmerican Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons; 11(1): 169-72en_US
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11175en
dc.description.abstractMulticentric Castleman disease is a lymphoproliferative disorder which when seen in the setting of HIV/AIDS is often associated with human herpes virus 8 (HHV-8) infection. We describe the case of a HIV-negative man who developed HHV-8-associated multicentric Castleman disease 11 years after liver transplantation. The patient presented with fevers and weight loss. Physical examination revealed enlarged cervical, axillary and inguinal lymph nodes. Widespread lymphadenopathy was confirmed on computed tomography (CT) scanning. Histology of an enlarged lymph node showed a polymorphous infiltrate with mature plasma cells, plasmacytoid lymphocytes and occasional blasts within the cortex and paracortex. The diagnosis of Castleman disease was confirmed by the finding of numerous HHV-8-immunopositive cells around the regressed lymph node follicles and the detection of HHV-8 on plasma PCR. Although the conventional treatment for this condition has been combination chemotherapy, in the post-transplant context it was decided to treat the patient with valganciclovir and cessation of immunosuppression. His symptoms resolved rapidly and repeat plasma PCR done 3 months after starting treatment was negative for HHV-8. A follow-up CT scan showed a dramatic reduction in the size and amount of lymphadenopathy. After 15 months of treatment, he remains well with no evidence of graft dysfunction or rejection.en_US
dc.language.isoenen
dc.subject.otherGanciclovir.analogs & derivatives.therapeutic useen
dc.subject.otherGiant Lymph Node Hyperplasia.drug therapy.etiology.pathologyen
dc.subject.otherHumansen
dc.subject.otherLiver Transplantationen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.titlePost-liver transplantation multicentric Castleman disease treated with valganciclovir and weaning of immunosuppression.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleAmerican Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeonsen_US
dc.identifier.affiliationVictorian Liver Transplant Uniten_US
dc.identifier.doi10.1111/j.1600-6143.2010.03366.xen_US
dc.description.pages169-72en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/21199357en
dc.type.contentTexten_US
dc.type.austinJournal Articleen
local.name.researcherAngus, Peter W
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

16
checked on Mar 28, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.