Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11120
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBahar-Fuchs, Alexen
dc.contributor.authorMoss, Simonen
dc.contributor.authorRowe, Christopher Cen
dc.contributor.authorSavage, Gregen
dc.date.accessioned2015-05-16T00:42:27Z
dc.date.available2015-05-16T00:42:27Z
dc.date.issued2010-09-24en
dc.identifier.citationChemical Senses 2010; 35(9): 855-62en
dc.identifier.govdoc20870956en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/11120en
dc.description.abstractOlfactory dysfunction constitutes one of the earliest signs of Alzheimer's disease (AD) and has been shown in individuals with amnestic mild cognitive impairment (aMCI). Whether the severity of olfactory impairments in aMCI patients parallels those in AD has not been clearly established. In addition, given reports of asymmetries in neuropathological burden in early AD, functional asymmetries in olfactory performance may enhance early detection if olfactory function is assessed unirhinally. We compared AD, aMCI, and healthy participants on olfactory identification and memory assessed unirhinally. Olfactory identification was most proficient in the healthy participants and least proficient in AD, although this disparity did not depend on nostril side. Nevertheless, when only the worst nostril of each participant was included in the analysis, aMCI patients outperformed their AD counterparts. In contrast, when only the best nostril of each participant was included in the analysis--often regarded as an estimate of birhinal performance--this difference between aMCI and AD dissipated. Olfactory memory did not differ significantly across the groups, perhaps reflecting a floor effect. The findings support the hypothesis that unirhinal olfactory assessment may assist in differentiating between demented and nondemented individuals.en
dc.language.isoenen
dc.subject.otherAgeden
dc.subject.otherAging.physiologyen
dc.subject.otherAlzheimer Disease.physiopathologyen
dc.subject.otherAmnesia.physiopathologyen
dc.subject.otherCognition Disorders.physiopathologyen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMemory.classification.physiologyen
dc.subject.otherNeuropsychological Testsen
dc.subject.otherOlfaction Disorders.physiopathologyen
dc.subject.otherSeverity of Illness Indexen
dc.titleOlfactory performance in AD, aMCI, and healthy ageing: a unirhinal approach.en
dc.typeJournal Articleen
dc.identifier.journaltitleChemical sensesen
dc.identifier.affiliationDepartment of Nuclear Medicine, Austin Health, 145 Studely Road, Heidelberg, Victoria 3804, Australiaen
dc.identifier.doi10.1093/chemse/bjq094en
dc.description.pages855-62en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/20870956en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptMolecular Imaging and Therapy-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

2
checked on Feb 5, 2023

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.