Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11097
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dc.contributor.authorCarney, Patrick Wen
dc.contributor.authorMasterton, Richard A Jen
dc.contributor.authorHarvey, A Simonen
dc.contributor.authorScheffer, Ingrid Een
dc.contributor.authorBerkovic, Samuel Fen
dc.contributor.authorJackson, Graeme Den
dc.date.accessioned2015-05-16T00:41:05Z
dc.date.available2015-05-16T00:41:05Z
dc.date.issued2010-08-11en
dc.identifier.citationNeurology 2010; 75(10): 904-11en
dc.identifier.govdoc20702791en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11097en
dc.description.abstractWe used EEG-fMRI to study epileptiform activity in a cohort of untreated children with typical absence seizures (AS). Our aim was to identify cortical and subcortical regions involved in spike and wave events and to explore the timing of activity in these regions.Eleven children with AS confirmed on video-EEG underwent EEG-fMRI. An event-related analysis of epileptiform activity was performed. Regions of interest (ROIs), identified in the event-related analysis, were used to study the time course of the blood oxygen level-dependent (BOLD) signal prior to and immediately following events of interest in these ROIs.Group analysis confirmed positive BOLD in the thalamus and negative BOLD in the lateral and mesial parietal lobe, caudate nuclei, and additionally the brainstem reticular formation. The event-related time course differed between the thalamus, the parietal cortex, and the pons and caudate nuclei. In the subcortical structures, BOLD signal change occurred at, or immediately after, electrographic onset. Importantly, in the parietal cortex, but not in other cortical regions, there was a subtle BOLD signal increase for 10 seconds prior to the onset of epileptiform activity.In children with typical AS, we have confirmed a core network of structures involved in generalized epileptiform activity that includes the reticular structures of the brainstem. Furthermore, we have identified changes in parietal BOLD signal which precede the onset of epileptiform activity, suggesting the parietal cortex has a role in the initiation of epileptiform activity.en
dc.language.isoenen
dc.subject.otherAdolescenten
dc.subject.otherBrain Mappingen
dc.subject.otherCerebral Cortex.physiopathologyen
dc.subject.otherChilden
dc.subject.otherChild, Preschoolen
dc.subject.otherElectroencephalographyen
dc.subject.otherEpilepsy, Absence.physiopathologyen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherImage Processing, Computer-Assisteden
dc.subject.otherMagnetic Resonance Imagingen
dc.subject.otherMaleen
dc.subject.otherNerve Net.physiopathologyen
dc.subject.otherPatient Selectionen
dc.subject.otherSignal Processing, Computer-Assisteden
dc.subject.otherThalamus.physiopathologyen
dc.titleThe core network in absence epilepsy. Differences in cortical and thalamic BOLD response.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeurologyen
dc.identifier.affiliationBrain Research Institute, Florey Neurosciences Institutes, Neurosciences Building, Heidelberg Repatriation Hospital, Austin Health, West Heidelberg, Victoria 3081, Australiaen
dc.identifier.doi10.1212/WNL.0b013e3181f11c06en
dc.description.pages904-11en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/20702791en
dc.type.austinJournal Articleen
local.name.researcherBerkovic, Samuel F
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptNeurology-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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