Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11088
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dc.contributor.authorYunos, Nor'azim Mohden
dc.contributor.authorBellomo, Rinaldoen
dc.contributor.authorStory, David Aen
dc.contributor.authorKellum, Johnen
dc.date.accessioned2015-05-16T00:40:13Z
dc.date.available2015-05-16T00:40:13Z
dc.date.issued2010-07-08en
dc.identifier.citationCritical Care 2010; 14(4): 226en
dc.identifier.govdoc20663180en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/11088en
dc.description.abstractChloride is the principal anion in the extracellular fluid and is the second main contributor to plasma tonicity. Its concentration is frequently abnormal in intensive care unit patients, often as a consequence of fluid therapy. Yet chloride has received less attention than any other ion in the critical care literature. New insights into its physiological roles have emerged together with progress in understanding the structures and functions of chloride channels. In clinical practice, interest in a physicochemical approach to acid-base physiology has directed renewed attention to chloride as a major determinant of acid-base status. It has also indirectly helped to generate interest in other possible effects of disorders of chloraemia. The present review summarizes key aspects of chloride physiology, including its channels, as well as the clinical relevance of disorders of chloraemia. The paper also highlights current knowledge on the impact of different types of intravenous fluids on chloride concentration and the potential effects of such changes on organ physiology. Finally, the review examines the potential intensive care unit practice implications of a better understanding of chloride.en
dc.language.isoenen
dc.subject.otherAcid-Base Equilibrium.physiologyen
dc.subject.otherAnimalsen
dc.subject.otherChloride Channels.physiologyen
dc.subject.otherChlorides.blood.physiologyen
dc.subject.otherCritical Illnessen
dc.subject.otherFluid Therapy.adverse effects.methodsen
dc.subject.otherGastrointestinal Tract.physiology.physiopathologyen
dc.subject.otherHumansen
dc.subject.otherIntensive Care.methodsen
dc.subject.otherKidney.physiology.physiopathologyen
dc.subject.otherSepsis.physiopathology.therapyen
dc.titleBench-to-bedside review: Chloride in critical illness.en
dc.typeJournal Articleen
dc.identifier.journaltitleCritical Careen
dc.identifier.affiliationnor.azim@med.monash.edu.myen
dc.identifier.affiliationDepartment of Intensive Care, Austin Hospital, Heidelberg, Melbourne, VIC 33084, Australiaen
dc.identifier.doi10.1186/cc9052en
dc.description.pages226en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/20663180en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
crisitem.author.deptAnaesthesia-
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