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https://ahro.austin.org.au/austinjspui/handle/1/11041| Title: | Comparison of ?-endorphin immunoreactivity in hypothalamic and brainstem nuclei of normotensive and age-matched hypertensive rat strains. | Austin Authors: | Conway, Elizabeth L;Maccarrone, C;Jarrott, B;Louis, William J | Affiliation: | University of Melbourne, Clinical Pharmacology and Therapeutics Unit, Department of Medicine, Austin Hospital, Heidelberg, 3084, Australia | Issue Date: | 16-May-1986 | Publication information: | Neurochemistry International; 9(2): 273-9 | Abstract: | The concentration of ?-endorphin immunoreactivity was determined in 21 hypothalamic and brainstem nuclei of Sprague-Dawley (SD) and 6 and 14 week Wistar-Kyoto (WKY) and Spontaneously Hypertensive (SH) rats. The concentrations of ?-endorphin immunoreactivity were greater in the hypothalamic nuclei than in the brainstem nuclei approximately by a factor of 5. A significant strain-age interaction was observed in the ?-endorphin immunoreactivity levels in the anterior hypothalamic area, paragigantocellular reticular nucleus and locus coeruleus of age-matched SH and WKY rats in that immunoreactivity levels fell in the age period studied (6-14 weeks) in WKY rats and rose in SH rats. These biochemical differences are related in time to a growth period during which there are large increases in blood pressure in the SH rat and may thus have a pathogenetic significance. | Gov't Doc #: | 20493126 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/11041 | Journal: | Neurochemistry international | URL: | https://pubmed.ncbi.nlm.nih.gov/20493126 | Type: | Journal Article |
| Appears in Collections: | Journal articles |
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