Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11029
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dc.contributor.authorHaase, Michaelen
dc.contributor.authorBellomo, Rinaldoen
dc.contributor.authorHaase-Fielitz, Anjaen
dc.date.accessioned2015-05-16T00:36:28Z
dc.date.available2015-05-16T00:36:28Z
dc.date.issued2010-05-11en
dc.identifier.citationJournal of the American College of Cardiology; 55(19): 2024-33en
dc.identifier.govdoc20447525en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11029en
dc.description.abstractCardiac surgery-associated acute kidney injury (AKI) is common and carries a poor prognosis. Hemodynamic and inflammatory factors and the release of labile iron, contributing to oxidation from reactive oxygen species are among the major determinants of cardiac surgery-associated AKI. The diagnosis of AKI is typically delayed because of the limitations of currently used clinical biomarkers indicating loss of renal function. However, several novel renal biomarkers, which predict AKI or protection from AKI after cardiopulmonary bypass (CPB), have been identified as early markers of kidney injury. In this state-of-the-art review, the authors analyze the pathophysiological implications of recent findings regarding novel renal biomarkers in relation to CPB-associated AKI. Neutrophil gelatinase-associated lipocalin, liver-type fatty acid-binding protein, and alpha-1 microglobulin predict the development of CPB-associated AKI, while hepcidin isoforms appear to predict protection from it, and these biomarkers are involved in iron metabolism. Neutrophil gelatinase-associated lipocalin participates in local iron transport. Liver-type fatty acid-binding protein and alpha-1 microglobulin function as high-affinity heme-binding proteins in different species, while hepcidin is central to iron sequestration and when increased in the urine appears to protect from CPB-associated AKI. Free iron-related, reactive oxygen species-mediated kidney injury appears to be the unifying pathophysiological connection for these biomarkers. Such novel findings on renal tubular biomarkers were further combined with other lines of evidence related to hemolysis during CPB, the associated excess of free heme and iron, knowledge of the effect of free iron on renal tubular cells, and recent trial evidence targeting free iron-mediated mechanisms of AKI. Novel biomarkers point toward free iron-mediated toxicity to be an important mechanism of AKI in patients receiving cardiac surgery with CPB.en
dc.language.isoenen
dc.subject.otherAcute Kidney Injury.diagnosis.etiology.metabolismen
dc.subject.otherBiological Markers.metabolismen
dc.subject.otherCardiopulmonary Bypass.adverse effectsen
dc.subject.otherHumansen
dc.subject.otherIron Overload.etiology.metabolism.physiopathologyen
dc.subject.otherOxidative Stress.physiologyen
dc.titleNovel biomarkers, oxidative stress, and the role of labile iron toxicity in cardiopulmonary bypass-associated acute kidney injury.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of the American College of Cardiologyen
dc.identifier.affiliationDepartment of Intensive Care, Austin Health, Melbourne, Australiaen
dc.identifier.doi10.1016/j.jacc.2009.12.046en
dc.description.pages2024-33en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/20447525en
dc.type.austinJournal Articleen
local.name.researcherBellomo, Rinaldo
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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