Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11001
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dc.contributor.authorBadawy, Radwa A Ben
dc.contributor.authorMacdonell, Richard A Len
dc.contributor.authorJackson, Graeme Den
dc.contributor.authorBerkovic, Samuel Fen
dc.date.accessioned2015-05-16T00:34:48Z
dc.date.available2015-05-16T00:34:48Z
dc.date.issued2010-10-01en
dc.identifier.citationEpilepsia; 51(10): 2084-8en
dc.identifier.govdoc20384725en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11001en
dc.description.abstractWe used transcranial magnetic stimulation (TMS) to investigate whether there were any characteristic cortical excitability changes in progressive myoclonic epilepsy (PME) compared to juvenile myoclonic epilepsy (JME).Six patients with PME were studied. Motor threshold (MT) at rest and recovery curve analysis using paired-pulse stimulation at a number of interstimulus intervals (ISIs) was determined. Results were compared to those of 9 patients with chronic refractory JME and 10 with chronic well-controlled JME.PME showed a marked increase in cortical excitability at all the long ISIs (p < 0.01), compared to refractory JME (effect sizes ranging from 1.4 to 1.9) and well-controlled JME (effect sizes ranging from 2.0 to 2.4). Significant differences at the short ISIs 2-5 ms were seen only on comparison with the well-controlled group (p < 0.05, effect size 0.6, 0.7). There were no significant differences in MTs of PME compared to either JME groups.Our findings demonstrate specific differences in cortical excitability using TMS between PME and those with JME, particularly at long latencies in the paired-pulse paradigm, implicating a role for γ-aminobutyric acid (GABA)(B) -mediated networks.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAnticonvulsants.therapeutic useen
dc.subject.otherCerebral Cortex.physiopathologyen
dc.subject.otherChronic Diseaseen
dc.subject.otherDiagnosis, Differentialen
dc.subject.otherDrug Resistanceen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherMotor Cortex.physiopathologyen
dc.subject.otherMyoclonic Epilepsies, Progressive.diagnosis.drug therapy.physiopathologyen
dc.subject.otherMyoclonic Epilepsy, Juvenile.diagnosis.drug therapy.physiopathologyen
dc.subject.otherTranscranial Magnetic Stimulation.methods.statistics & numerical dataen
dc.subject.otherUnverricht-Lundborg Syndrome.diagnosis.physiopathologyen
dc.subject.othergamma-Aminobutyric Acid.physiologyen
dc.titleCan changes in cortical excitability distinguish progressive from juvenile myoclonic epilepsy?en
dc.typeJournal Articleen
dc.identifier.journaltitleEpilepsiaen
dc.identifier.affiliationDepartment of Neurology, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1111/j.1528-1167.2010.02557.xen
dc.description.pages2084-8en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/20384725en
dc.type.austinJournal Articleen
local.name.researcherBerkovic, Samuel F
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptNeurology-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
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